Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus

Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocr...

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Veröffentlicht in:	Cell death and differentiation 2020-04, Vol.27 (4), p.1415-1430
Hauptverfasser:	Chen, Xiaoyan, Wang, Huiming, Yu, Mengliu, Kim, Jong Kil, Qi, Huichuan, Ha, Pin, Jiang, Wenlu, Chen, Eric, Luo, Xiangyou, Needle, Ryan Brent, Baik, Lloyd, Yang, Cathryn, Shi, Jiejun, Kwak, Jin Hee, Ting, Kang, Zhang, Xinli, Soo, Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/475 631/92 82/1 Animals Animals, Newborn Apoptosis Biochemistry Biochemistry & Molecular Biology Biomedical and Life Sciences Birth defects Bone dysplasia Bones Calcium-Binding Proteins - metabolism Cell Biology Cell cycle Cell Cycle Analysis Cell Differentiation Cell growth Cell Lineage Cell proliferation Cerebrospinal fluid Choroid plexus Cranial sutures Craniofacial Abnormalities - complications Craniofacial Abnormalities - pathology Craniofacial growth Craniofacial syndromes Craniosynostosis Down-Regulation Embryos Ependymal cells Epithelial cells Ethyl nitrosourea Female Histology Homeostasis Hydrocephalus Hydrocephalus - complications Hydrocephalus - pathology Hypoplasia Lethality Life Sciences Life Sciences & Biomedicine Mandible Mice, Inbred C57BL Mice, Knockout Microscopy Mutagenesis Mutation - genetics Neonates Neural crest Neural Crest - pathology Ossification Osteocalcin Osteochondrodysplasias - complications Osteochondrodysplasias - pathology Osteogenesis Penetrance Phenotypes Proteins Rodents Science & Technology Skeletogenesis Skull Stem Cells Sutures Wnt Signaling Pathway Wnt1 Protein - metabolism
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