Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats
•Periodontitis as a risk factor for human tooth loss.•An atherogenic diet and the onset and progression of periodontitis.•Fish oil and the prevention of bone resorption.•The therapeutic benefit of fish oil for hypercholesterolemic patients with periodontitis. This study evaluated the effects of repl...
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| Veröffentlicht in: | Archives of oral biology 2020-01, Vol.109, p.104553-104553, Article 104553 |
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| container_title | Archives of oral biology |
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| creator | Antona, María Eugenia Ramos, Cecilia Stranges, Andrea Monteiro, Andrea Ferreira Gonzales Chaves, María Macarena Mandalunis, Patricia Zago, Valeria Friedman, Silvia María Macri, Elisa Vanesa |
| description | •Periodontitis as a risk factor for human tooth loss.•An atherogenic diet and the onset and progression of periodontitis.•Fish oil and the prevention of bone resorption.•The therapeutic benefit of fish oil for hypercholesterolemic patients with periodontitis.
This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD).
Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2).
Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p |
| doi_str_mv | 10.1016/j.archoralbio.2019.104553 |
| format | Article |
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This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD).
Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2).
Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p < 0.001).
In all rats the ligated teeth showed a greater bone loss as compared with the unligated molars. At the end of the experiment the AT + L was the worst in % lower bone volume (p < 0.01), hPDL and PBS (p < 0.05). In contrast, rats fed n-3PUFA + L was similar to those rats fed C diet (p > 0.05).
Alveolar bone and dyslipidemia improved by substituting saturated fat intake for a n-3PUFA rich diet, in hypercholesterolemic rats with PD.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2019.104553</identifier><identifier>PMID: 31563004</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alveolar bone loss ; Alveolar Bone Loss - therapy ; Animals ; Dentistry ; Diet ; Dyslipidemias - therapy ; Fatty Acids, Omega-3 - administration & dosage ; Fish oil ; Fish Oils - administration & dosage ; Hypercholesterolemia ; Hypercholesterolemia - physiopathology ; Periodontitis ; Periodontitis - physiopathology ; Random Allocation ; Rat ; Rats ; Rats, Wistar</subject><ispartof>Archives of oral biology, 2020-01, Vol.109, p.104553-104553, Article 104553</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-43f884583dff01a5b27d7de21d34b6336d9874cc4a670e36ce7702e22ea4262f3</citedby><cites>FETCH-LOGICAL-c377t-43f884583dff01a5b27d7de21d34b6336d9874cc4a670e36ce7702e22ea4262f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2019.104553$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31563004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antona, María Eugenia</creatorcontrib><creatorcontrib>Ramos, Cecilia</creatorcontrib><creatorcontrib>Stranges, Andrea</creatorcontrib><creatorcontrib>Monteiro, Andrea Ferreira</creatorcontrib><creatorcontrib>Gonzales Chaves, María Macarena</creatorcontrib><creatorcontrib>Mandalunis, Patricia</creatorcontrib><creatorcontrib>Zago, Valeria</creatorcontrib><creatorcontrib>Friedman, Silvia María</creatorcontrib><creatorcontrib>Macri, Elisa Vanesa</creatorcontrib><title>Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>•Periodontitis as a risk factor for human tooth loss.•An atherogenic diet and the onset and progression of periodontitis.•Fish oil and the prevention of bone resorption.•The therapeutic benefit of fish oil for hypercholesterolemic patients with periodontitis.
This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD).
Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2).
Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p < 0.001).
In all rats the ligated teeth showed a greater bone loss as compared with the unligated molars. At the end of the experiment the AT + L was the worst in % lower bone volume (p < 0.01), hPDL and PBS (p < 0.05). In contrast, rats fed n-3PUFA + L was similar to those rats fed C diet (p > 0.05).
Alveolar bone and dyslipidemia improved by substituting saturated fat intake for a n-3PUFA rich diet, in hypercholesterolemic rats with PD.</description><subject>Alveolar bone loss</subject><subject>Alveolar Bone Loss - therapy</subject><subject>Animals</subject><subject>Dentistry</subject><subject>Diet</subject><subject>Dyslipidemias - therapy</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fish oil</subject><subject>Fish Oils - administration & dosage</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - physiopathology</subject><subject>Periodontitis</subject><subject>Periodontitis - physiopathology</subject><subject>Random Allocation</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9LAzEQxYMotla_gsSbB7fmz26yOUqxKghe9ByyySxNSTc12Qp-e1Oq4tHTMMObeW9-CF1RMqeEitv13CS7ismEzsc5I1SVed00_AhNaStVRRsijtGUEMIrpYSaoLOc16VthKCnaMJpIzgh9RQ9LX1e4egDdh5GDH0Pdsw4DtiED4jBJNzFAXCIOd9gP-DV5xb25gHyCKmUjbc4mTGfo5PehAwX33WG3pb3r4vH6vnl4Wlx91xZLuVY1bxv27ppuet7Qk3TMemkA0YdrzvBuXCqlbW1tRGSABcWpCQMGANTM8F6PkPXh7vbFN93JYXe-GwhBDNA3GXNmFKUt4S1RaoOUptK_AS93ia_MelTU6L3JPVa_yGp9yT1gWTZvfy22XUbcL-bP-iKYHEQQHn2w0PS2XoYLDifCkPtov-HzResHYoJ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Antona, María Eugenia</creator><creator>Ramos, Cecilia</creator><creator>Stranges, Andrea</creator><creator>Monteiro, Andrea Ferreira</creator><creator>Gonzales Chaves, María Macarena</creator><creator>Mandalunis, Patricia</creator><creator>Zago, Valeria</creator><creator>Friedman, Silvia María</creator><creator>Macri, Elisa Vanesa</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats</title><author>Antona, María Eugenia ; Ramos, Cecilia ; Stranges, Andrea ; Monteiro, Andrea Ferreira ; Gonzales Chaves, María Macarena ; Mandalunis, Patricia ; Zago, Valeria ; Friedman, Silvia María ; Macri, Elisa Vanesa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-43f884583dff01a5b27d7de21d34b6336d9874cc4a670e36ce7702e22ea4262f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alveolar bone loss</topic><topic>Alveolar Bone Loss - therapy</topic><topic>Animals</topic><topic>Dentistry</topic><topic>Diet</topic><topic>Dyslipidemias - therapy</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fish oil</topic><topic>Fish Oils - administration & dosage</topic><topic>Hypercholesterolemia</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Periodontitis</topic><topic>Periodontitis - physiopathology</topic><topic>Random Allocation</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antona, María Eugenia</creatorcontrib><creatorcontrib>Ramos, Cecilia</creatorcontrib><creatorcontrib>Stranges, Andrea</creatorcontrib><creatorcontrib>Monteiro, Andrea Ferreira</creatorcontrib><creatorcontrib>Gonzales Chaves, María Macarena</creatorcontrib><creatorcontrib>Mandalunis, Patricia</creatorcontrib><creatorcontrib>Zago, Valeria</creatorcontrib><creatorcontrib>Friedman, Silvia María</creatorcontrib><creatorcontrib>Macri, Elisa Vanesa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antona, María Eugenia</au><au>Ramos, Cecilia</au><au>Stranges, Andrea</au><au>Monteiro, Andrea Ferreira</au><au>Gonzales Chaves, María Macarena</au><au>Mandalunis, Patricia</au><au>Zago, Valeria</au><au>Friedman, Silvia María</au><au>Macri, Elisa Vanesa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>109</volume><spage>104553</spage><epage>104553</epage><pages>104553-104553</pages><artnum>104553</artnum><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>•Periodontitis as a risk factor for human tooth loss.•An atherogenic diet and the onset and progression of periodontitis.•Fish oil and the prevention of bone resorption.•The therapeutic benefit of fish oil for hypercholesterolemic patients with periodontitis.
This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD).
Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2).
Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p < 0.001).
In all rats the ligated teeth showed a greater bone loss as compared with the unligated molars. At the end of the experiment the AT + L was the worst in % lower bone volume (p < 0.01), hPDL and PBS (p < 0.05). In contrast, rats fed n-3PUFA + L was similar to those rats fed C diet (p > 0.05).
Alveolar bone and dyslipidemia improved by substituting saturated fat intake for a n-3PUFA rich diet, in hypercholesterolemic rats with PD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31563004</pmid><doi>10.1016/j.archoralbio.2019.104553</doi><tpages>1</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2020-01, Vol.109, p.104553-104553, Article 104553 |
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| subjects | Alveolar bone loss Alveolar Bone Loss - therapy Animals Dentistry Diet Dyslipidemias - therapy Fatty Acids, Omega-3 - administration & dosage Fish oil Fish Oils - administration & dosage Hypercholesterolemia Hypercholesterolemia - physiopathology Periodontitis Periodontitis - physiopathology Random Allocation Rat Rats Rats, Wistar |
| title | Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats |
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