Utilization of 18 F-Fluorodeoxyglucose-Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo

Cancer cells are highly dependent on NAD /NADH produced via the nicotinamide salvage pathway. The rate-limiting enzyme in this pathway is the nicotinamide phosphoribosyltransferase (NAMPT), which we have targeted with novel NAMPT inhibitors. NAMPT inhibition elicits depletion of total cellular NAD l...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2019-12, Vol.371 (3), p.583
Hauptverfasser:	Mudd, Sarah R, Voorbach, Martin J, Cheng, Dong, Cheng, Min, Guo, Jun, Gao, Wenqing, Buchanan, Fritz G, Tse, Chris, Wilsbacher, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Female Fluorodeoxyglucose F18 - pharmacokinetics HCT116 Cells Humans Mice NAD - metabolism Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Positron-Emission Tomography - methods Radiopharmaceuticals - pharmacokinetics
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