Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases

Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced. Two patients aged 31 and...

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Veröffentlicht in:La revue de medecine interne 2020-04, Vol.41 (4), p.289
Hauptverfasser: Bodard, Q, Carre, D, Chenal, P, Zarnitsky, C, Midhat, M, Litrowski, N
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Carre, D
Chenal, P
Zarnitsky, C
Midhat, M
Litrowski, N
description Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced. Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction. We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases.
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subjects Adrenal Cortex Hormones - therapeutic use
Adult
Diagnosis, Differential
Drug Substitution
Female
Humans
Hydroxychloroquine - adverse effects
Hydroxychloroquine - therapeutic use
Lupus Erythematosus, Systemic - drug therapy
Sjogren's Syndrome - drug therapy
Sweet Syndrome - chemically induced
Sweet Syndrome - diagnosis
title Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases
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