Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases
Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced. Two patients aged 31 and...
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Veröffentlicht in: | La revue de medecine interne 2020-04, Vol.41 (4), p.289 |
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creator | Bodard, Q Carre, D Chenal, P Zarnitsky, C Midhat, M Litrowski, N |
description | Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced.
Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.
We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases. |
doi_str_mv | 10.1016/j.revmed.2019.08.010 |
format | Article |
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Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.
We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases.</description><identifier>EISSN: 1768-3122</identifier><identifier>DOI: 10.1016/j.revmed.2019.08.010</identifier><identifier>PMID: 31540835</identifier><language>fre</language><publisher>France</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Adult ; Diagnosis, Differential ; Drug Substitution ; Female ; Humans ; Hydroxychloroquine - adverse effects ; Hydroxychloroquine - therapeutic use ; Lupus Erythematosus, Systemic - drug therapy ; Sjogren's Syndrome - drug therapy ; Sweet Syndrome - chemically induced ; Sweet Syndrome - diagnosis</subject><ispartof>La revue de medecine interne, 2020-04, Vol.41 (4), p.289</ispartof><rights>Copyright © 2019 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31540835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bodard, Q</creatorcontrib><creatorcontrib>Carre, D</creatorcontrib><creatorcontrib>Chenal, P</creatorcontrib><creatorcontrib>Zarnitsky, C</creatorcontrib><creatorcontrib>Midhat, M</creatorcontrib><creatorcontrib>Litrowski, N</creatorcontrib><title>Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases</title><title>La revue de medecine interne</title><addtitle>Rev Med Interne</addtitle><description>Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced.
Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.
We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adult</subject><subject>Diagnosis, Differential</subject><subject>Drug Substitution</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxychloroquine - adverse effects</subject><subject>Hydroxychloroquine - therapeutic use</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Sjogren's Syndrome - drug therapy</subject><subject>Sweet Syndrome - chemically induced</subject><subject>Sweet Syndrome - diagnosis</subject><issn>1768-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81KxDAURoMgzjj6BiLZuWq9t0ma1N0wjn8MuFDXQ9PcOh06bU1atW9vQV19cD44cBi7QIgRML3ex54-D-TiBDCLwcSAcMTmqFMTCUySGTsNYQ8wYcxO2EygkmCEmrOnWz-8R1XjhoIcf_ki6q8CD2PjfHsg7qnO--noW74bJ_Q9Fru69e3HUDV0w5e2HXqe8CIPFM7YcZnXgc7_dsHe7tavq4do83z_uFpuoi5B7CNEMGS0tlaZUqY6F1CCEghayczaUmpJRKm1IpWJyFzm0AgplUJNaaZysWCXv95usFPztvPVIffj9j9K_ACe6U29</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Bodard, Q</creator><creator>Carre, D</creator><creator>Chenal, P</creator><creator>Zarnitsky, C</creator><creator>Midhat, M</creator><creator>Litrowski, N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202004</creationdate><title>Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases</title><author>Bodard, Q ; Carre, D ; Chenal, P ; Zarnitsky, C ; Midhat, M ; Litrowski, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-1108e877bb58f467a30f053107549bbf474eee6bb364239d9d183445517e695a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2020</creationdate><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Diagnosis, Differential</topic><topic>Drug Substitution</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxychloroquine - adverse effects</topic><topic>Hydroxychloroquine - therapeutic use</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Sjogren's Syndrome - drug therapy</topic><topic>Sweet Syndrome - chemically induced</topic><topic>Sweet Syndrome - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bodard, Q</creatorcontrib><creatorcontrib>Carre, D</creatorcontrib><creatorcontrib>Chenal, P</creatorcontrib><creatorcontrib>Zarnitsky, C</creatorcontrib><creatorcontrib>Midhat, M</creatorcontrib><creatorcontrib>Litrowski, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>La revue de medecine interne</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bodard, Q</au><au>Carre, D</au><au>Chenal, P</au><au>Zarnitsky, C</au><au>Midhat, M</au><au>Litrowski, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases</atitle><jtitle>La revue de medecine interne</jtitle><addtitle>Rev Med Interne</addtitle><date>2020-04</date><risdate>2020</risdate><volume>41</volume><issue>4</issue><spage>289</spage><pages>289-</pages><eissn>1768-3122</eissn><abstract>Hydroxychloroquine is widely prescribed in systemic lupus erythematosus. Dermatologic adverse drug reactions are rare but can mimic a disease specific manifestation of lupus. Exceptionally, Sweet's syndrome, or acute febrile neutrophilic dermatosis, may be drug-induced.
Two patients aged 31 and 42 years were treated with hydroxychloroquine for systemic lupus and Sjogren's syndrome, respectively. Three weeks after starting treatment, they had a febrile, purple and erythematous papular rash of the trunk and limbs. There was a biological inflammatory syndrome and skin biopsy disclosed an infiltrate of the dermis rich in neutrophils. Lesions regressed after stopping hydroxychloroquine and introducing systemic corticosteroid therapy. Allergologic tests discussed the differential diagnosis with a delayed-type hypersensitivity reaction.
We report two exceptional cases of drug-induced Sweet's syndrome related to hydroxychloroquine treatment in autoimmune rheumatic diseases.</abstract><cop>France</cop><pmid>31540835</pmid><doi>10.1016/j.revmed.2019.08.010</doi></addata></record> |
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source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
subjects | Adrenal Cortex Hormones - therapeutic use Adult Diagnosis, Differential Drug Substitution Female Humans Hydroxychloroquine - adverse effects Hydroxychloroquine - therapeutic use Lupus Erythematosus, Systemic - drug therapy Sjogren's Syndrome - drug therapy Sweet Syndrome - chemically induced Sweet Syndrome - diagnosis |
title | Drug-induced Sweet's syndrome related to hydroxychloroquine: About 2 cases |
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