Life-Threatening Extrarenal Manifestations in an Infant with Atypical Hemolytic Uremic Syndrome Caused by a Complement 3-Gene Mutation

Abstract Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment caused by uncontrolled activation of the complement system. About 20% of patients show extrarenal manifestatio...

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Veröffentlicht in:	Kidney & blood pressure research 2019-10, Vol.44 (5), p.1300-1305
Hauptverfasser:	Han, Sa Ra, Cho, Myung Hyun, Moon, Jin Soo, Ha, Il Soo, Cheong, Hae Il, Kang, Hee Gyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Anemia Atypical hemolytic uremic syndrome Atypical Hemolytic Uremic Syndrome - complications Binding sites Biopsy Bleeding Blood Blood platelets Care and treatment Case Report Case studies Central nervous system Complement Complement (Immunology) Complement activation Complement C3 - genetics Complement component C3 Creatinine Dehydrogenases Diagnosis Eculizumab Esophagus Extrarenal manifestations Female Gastrointestinal bleeding Gastrointestinal hemorrhage Gene mutation Gene mutations Genes Genetic aspects Health aspects Health services Heart rate Hemodialysis Hemoglobin Hemolytic anemia Hemolytic uremic syndrome Hemorrhage Humans Infant Infants Jaundice Laboratory tests Mutation Patients Pediatric diseases Pediatric research Pediatrics Plasma Point mutation Pulmonary hemorrhage Purpura Remission (Medicine) Renal function Renal replacement therapy Skin Thrombocytopenia Transfusion Urine
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