Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitro
Abstract This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli. This was demonstrated by growth inhibition of Escherichia coli and Pseudomonas...
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| Veröffentlicht in: | Journal of microencapsulation 1988, Vol.5 (4), p.303-309 |
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| container_end_page | 309 |
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| container_issue | 4 |
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| container_title | Journal of microencapsulation |
| container_volume | 5 |
| creator | Nacucchio, Marcelo C. Gatto Bellora, Mauricio J. Sordelli, Daniel O. D'aquino, Miguel |
| description | Abstract
This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli. This was demonstrated by growth inhibition of Escherichia coli and Pseudomonas aeruginosa in the presence of the liposomal preparations containing either PIP or GE at 50 per cent MIC. Mixtures of liposomes containing buffer and either PIP or GE also exhibited an enhanced activity of the drug against the micro-organisms. |
| doi_str_mv | 10.3109/02652048809036726 |
| format | Article |
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This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli. This was demonstrated by growth inhibition of Escherichia coli and Pseudomonas aeruginosa in the presence of the liposomal preparations containing either PIP or GE at 50 per cent MIC. Mixtures of liposomes containing buffer and either PIP or GE also exhibited an enhanced activity of the drug against the micro-organisms.</description><identifier>ISSN: 0265-2048</identifier><identifier>EISSN: 1464-5246</identifier><identifier>DOI: 10.3109/02652048809036726</identifier><identifier>PMID: 3148705</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Drug Carriers ; Drug Resistance, Microbial ; Escherichia coli ; Escherichia coli - drug effects ; Gentamicins - pharmacology ; Liposomes ; Penicillin Resistance ; Piperacillin - pharmacology ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects</subject><ispartof>Journal of microencapsulation, 1988, Vol.5 (4), p.303-309</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-379ca6eddd93d03fd422ed7a757fdd117e28c93f6af859c6255a54dc86b37633</citedby><cites>FETCH-LOGICAL-c347t-379ca6eddd93d03fd422ed7a757fdd117e28c93f6af859c6255a54dc86b37633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02652048809036726$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02652048809036726$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4022,27922,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3148705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nacucchio, Marcelo C.</creatorcontrib><creatorcontrib>Gatto Bellora, Mauricio J.</creatorcontrib><creatorcontrib>Sordelli, Daniel O.</creatorcontrib><creatorcontrib>D'aquino, Miguel</creatorcontrib><title>Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitro</title><title>Journal of microencapsulation</title><addtitle>J Microencapsul</addtitle><description>Abstract
This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli. This was demonstrated by growth inhibition of Escherichia coli and Pseudomonas aeruginosa in the presence of the liposomal preparations containing either PIP or GE at 50 per cent MIC. Mixtures of liposomes containing buffer and either PIP or GE also exhibited an enhanced activity of the drug against the micro-organisms.</description><subject>Drug Carriers</subject><subject>Drug Resistance, Microbial</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Gentamicins - pharmacology</subject><subject>Liposomes</subject><subject>Penicillin Resistance</subject><subject>Piperacillin - pharmacology</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><issn>0265-2048</issn><issn>1464-5246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY8_oD3Ah1MpdjXmnCt3IMD5gwM3si9t5dGdIJWWSduh_Pym6EUTUVR7nnI_LPQi9IfiaETy-x1QKivkw4BEzqah8hjaES94LyuVztFn1fjW8RJelPGCMxTjQC3TBCB8UFhv0eBv3ELU1XfBLKmm2_WyNh9p-IFa_BV1t9hC6dvE_fT12yXWLX2wG7UPwsdlMt7Oxwuz1-tyBj6V2uwxzH-0OWsx225O7a4YGyekVeuEgFPv6fF6h-8-39zdf-7vvX77dfLrrNeOq9kyNGqQ1xozMYOYMp9QaBUooZwwhytJBj8xJcIMYtaRCgOBGD3LLlGTsCr07YZecfhxsqdPsi7YhQLTpUCY1KCKpHP9rJIIwzvFKJCejzqmUbN20ZD9DPk4ET2sp0x-ltMzbM_ywbdv9lTi30PSPJ91Hl_IMjykHM1U4hpRdbvX4sqL_jv_wW3xvIdS9hmynh3TIse33H8M9AR3Rruc</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Nacucchio, Marcelo C.</creator><creator>Gatto Bellora, Mauricio J.</creator><creator>Sordelli, Daniel O.</creator><creator>D'aquino, Miguel</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitro</title><author>Nacucchio, Marcelo C. ; Gatto Bellora, Mauricio J. ; Sordelli, Daniel O. ; D'aquino, Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-379ca6eddd93d03fd422ed7a757fdd117e28c93f6af859c6255a54dc86b37633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Drug Carriers</topic><topic>Drug Resistance, Microbial</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Gentamicins - pharmacology</topic><topic>Liposomes</topic><topic>Penicillin Resistance</topic><topic>Piperacillin - pharmacology</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nacucchio, Marcelo C.</creatorcontrib><creatorcontrib>Gatto Bellora, Mauricio J.</creatorcontrib><creatorcontrib>Sordelli, Daniel O.</creatorcontrib><creatorcontrib>D'aquino, Miguel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of microencapsulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nacucchio, Marcelo C.</au><au>Gatto Bellora, Mauricio J.</au><au>Sordelli, Daniel O.</au><au>D'aquino, Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitro</atitle><jtitle>Journal of microencapsulation</jtitle><addtitle>J Microencapsul</addtitle><date>1988</date><risdate>1988</risdate><volume>5</volume><issue>4</issue><spage>303</spage><epage>309</epage><pages>303-309</pages><issn>0265-2048</issn><eissn>1464-5246</eissn><abstract>Abstract
This study showed that encapsulation of piperacillin (PIP) and gentamicin (GE) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) enhanced the antibiotic activity against gram negative bacilli. This was demonstrated by growth inhibition of Escherichia coli and Pseudomonas aeruginosa in the presence of the liposomal preparations containing either PIP or GE at 50 per cent MIC. Mixtures of liposomes containing buffer and either PIP or GE also exhibited an enhanced activity of the drug against the micro-organisms.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3148705</pmid><doi>10.3109/02652048809036726</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0265-2048 |
| ispartof | Journal of microencapsulation, 1988, Vol.5 (4), p.303-309 |
| issn | 0265-2048 1464-5246 |
| language | eng |
| recordid | cdi_pubmed_primary_3148705 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Drug Carriers Drug Resistance, Microbial Escherichia coli Escherichia coli - drug effects Gentamicins - pharmacology Liposomes Penicillin Resistance Piperacillin - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects |
| title | Enhanced liposome-mediated antibacterial activity of piperacillin and gentamicin against gram-negative bacilli in vitro |
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