Development and evaluation of a 99m Tc(V)-nitrido complex derived from estradiol for breast cancer imaging

Estrogen receptors are overexpressed in 70% of breast cancer and identification of their presence is important to select the appropriate treatment. This work proposes the preparation and evaluation of an estradiol derived as potential ER imaging agent. Ethinylestradiol was derivatized to introduce a...

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Veröffentlicht in:	Applied radiation and isotopes 2019-12, Vol.154, p.108854
Hauptverfasser:	Tejería, Emilia, Giglio, Javier, Fernández, Leticia, Rey, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Drug Stability Estradiol - analogs & derivatives Estradiol - chemical synthesis Estradiol - chemistry Female Humans MCF-7 Cells Mice Mice, Nude Neoplasm Transplantation Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - chemistry Organotechnetium Compounds - pharmacokinetics Protein Binding Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Receptors, Estrogen - metabolism Tissue Distribution
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