Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9

Circular antisense non-coding RNA in the INK4 locus (cANRIL) participated in inflammation of endothelial cells. However, whether cANRIL is associated with inflammatory injury of HK-2 cells, thereby affecting chronic kidney disease has not been investigated. We tested the hypothesis that cANRIL parti...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.3478-3484
Hauptverfasser:	Deng, Wenyan, Chen, Kai, Liu, Shuxia, Wang, Yingying
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense RNA Apoptosis Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Cell viability Chronic kidney disease circular ANRIL Cyclin-dependent kinase inhibitors Cytokines Endothelial cells Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Gene Silencing Humans Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - pathology Inflammatory response Injuries INK4 protein JNK Mitogen-Activated Protein Kinases - metabolism Kidney diseases lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - pharmacology microRNA-9 MicroRNAs MicroRNAs - genetics miRNA NF-kappa B - metabolism NF-κB protein Non-coding RNA p38 Mitogen-Activated Protein Kinases - metabolism Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction - drug effects Signal Transduction - genetics Transfection Up-Regulation - drug effects Up-Regulation - genetics
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