Identification of FOXN4 as a tumor suppressor of breast carcinogenesis via the activation of TP53 and deactivation of Notch signaling

Fork head domain-containing transcription factor family (FOX), is comprised of >20 members. Members of FOX family have been implicated in a wide range of physiological and/or diseased conditions. Many of FOX members have been shown to be involved in tumorigenesis and progression. The potential ro...

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Veröffentlicht in:	Gene 2020-01, Vol.722, p.144057
Hauptverfasser:	Wang, Xiao, Su, Dan, Qin, Zhiquan, Chen, Zheling
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium-Binding Proteins Carcinogenesis Cell Line, Tumor Cell Proliferation Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mice Neoplasm Metastasis Prognosis Receptors, Notch - antagonists & inhibitors Receptors, Notch - metabolism Signal Transduction Tetrahydronaphthalenes - therapeutic use Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Valine - analogs & derivatives Valine - therapeutic use
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