A photoregulated split aptaswitch for small molecules with improved sensitivity

A photoregulated split aptaswitch for small molecules with improved sensitivity

Here we show the design of a photoregulated split aptaswitch (PSA) for the challenging small-molecule biorecognition and its sensing application. The PSA specifically binds with the target in a binary reaction, and can easily rule out false positive signals by azobenzene photoisomerization, exhibiti...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-08, Vol.55 (64), p.9555-9558
Hauptverfasser: Wang, Ruoyu, Wu, Xueqi, Zhu, Xiyu, Shi, Hanchang, Zhou, Xiaohong
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Sensitivity
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container_issue 64
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container_title Chemical communications (Cambridge, England)
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creator Wang, Ruoyu
Wu, Xueqi
Zhu, Xiyu
Shi, Hanchang
Zhou, Xiaohong
description Here we show the design of a photoregulated split aptaswitch (PSA) for the challenging small-molecule biorecognition and its sensing application. The PSA specifically binds with the target in a binary reaction, and can easily rule out false positive signals by azobenzene photoisomerization, exhibiting an approximately 50-fold improved sensitivity over a control assay. Here we show the design of a photoregulated split aptaswitch (PSA) for the challenging small-molecule biorecognition and its sensing application.
doi_str_mv 10.1039/c9cc04083h
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subjects Sensitivity
title A photoregulated split aptaswitch for small molecules with improved sensitivity
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