Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants

Objectives: We aimed to determine the accuracy and validity of the Ultrasonic Cardiac Output Monitor (USCOM) measurements of cardiac output (CO) compared to echocardiography in newborn infants, and the inter-rater agreement of USCOM measurements. Methods: In a single-center study we prospectively ev...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neonatology (Basel, Switzerland) Switzerland), 2019-10, Vol.116 (3), p.260-268
Hauptverfasser: Fraga, María V., Dysart, Kevin C., Rintoul, Natalie, Chaudhary, Aasma S., Ratcliffe, Sarah J., Fedec, Anysia, Kren, Stephanie, Cohen, Meryl S., Kirpalani, Haresh
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 268
container_issue 3
container_start_page 260
container_title Neonatology (Basel, Switzerland)
container_volume 116
creator Fraga, María V.
Dysart, Kevin C.
Rintoul, Natalie
Chaudhary, Aasma S.
Ratcliffe, Sarah J.
Fedec, Anysia
Kren, Stephanie
Cohen, Meryl S.
Kirpalani, Haresh
description Objectives: We aimed to determine the accuracy and validity of the Ultrasonic Cardiac Output Monitor (USCOM) measurements of cardiac output (CO) compared to echocardiography in newborn infants, and the inter-rater agreement of USCOM measurements. Methods: In a single-center study we prospectively evaluated neonates undergoing an echocardiographic evaluation. USCOM measurements of CO were obtained at the pulmonary and aortic valve by 2 physicians blinded to the echocardiographic results. All echocardiographic measurements were performed blinded to USCOM measurements. We first enrolled an ascertainment cohort which was subsequently validated in an independent new cohort. Agreement between echocardiography and USCOM methods was assessed by Bland-Altman analysis. Intra-class correlation coefficients (ICC) assessed the agreement between the 2 operators. The ascertainment cohort correction factors were applied in a second validation cohort and agreement of the calibrated measures evaluated with repeat Bland-Altman comparisons. Results: A total of 50 infants were enrolled in the initial cohort and 15 in the validation cohort. There was a high degree of correlation between the USCOM operators (ICC = 0.975). USCOM measurements of CO were significantly higher compared to echocardiography (left ventricular output bias 95 ± 52 mL/kg/min and right ventricular output bias 64 ± 30 mL/kg/min). There was no difference in the subgroup of infants with and without a ductus arteriosus. After the correction was applied to the validation cohort, there was no longer a significant difference between the measures. Conclusions: CO measured by USCOM consistently overestimated the results obtained from echocardiography. USCOM is not adequate to provide absolute estimates of CO. However, it may allow longitudinal hemodynamic assessment of sick neonates.
doi_str_mv 10.1159/000501005
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmed_primary_31326967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A637779818</galeid><sourcerecordid>A637779818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-5c92c849323d3ade170a49b0be9b2a8816ff5e38c620cde18ff3abb427fe02db3</originalsourceid><addsrcrecordid>eNpt0c1vFCEUAPCJ0dhaPXg3hsTE6GErHzPM4G2zabVJ7R50vRIGHrvoDKzAxPS_L5tdV2saEiDwe488XlW9JPickEZ8wBg3mJTpUXVKOCeztiPi8XGP8Un1LKUfBTQNp0-rE0YY5YK3p9W4UNE4pdFyytspoy-g0hRhBJ_RKjm_RnkDaDXkqFLwTqP_fTnMIX5Ec_RdDc6o7IJHX_NkbpHz6AZ-9yF6dOWt8jk9r55YNSR4cVjPqtXlxbfF59n18tPVYn490zWjedZoQXVXC0aZYcoAabGqRY97ED1VXUe4tQ2wTnOKdbnurGWq72vaWsDU9OyserfPu43h1wQpy9ElDcOgPIQpSUo5ES2pCS70zZ6u1QDSeRtKqXrH5Zyztm1FR7qizh9QZRgYnQ4erCvn9wLe_hOwATXkTQrDtPuedB--30MdQ0oRrNxGN6p4KwmWu-7KY3eLfX0oa-pHMEf5p51_i_mp4hriEdxcLPcp5NbYol49qA6v3AFWFLJk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261971410</pqid></control><display><type>article</type><title>Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants</title><source>Karger Journals Complete</source><source>Alma/SFX Local Collection</source><creator>Fraga, María V. ; Dysart, Kevin C. ; Rintoul, Natalie ; Chaudhary, Aasma S. ; Ratcliffe, Sarah J. ; Fedec, Anysia ; Kren, Stephanie ; Cohen, Meryl S. ; Kirpalani, Haresh</creator><creatorcontrib>Fraga, María V. ; Dysart, Kevin C. ; Rintoul, Natalie ; Chaudhary, Aasma S. ; Ratcliffe, Sarah J. ; Fedec, Anysia ; Kren, Stephanie ; Cohen, Meryl S. ; Kirpalani, Haresh</creatorcontrib><description>Objectives: We aimed to determine the accuracy and validity of the Ultrasonic Cardiac Output Monitor (USCOM) measurements of cardiac output (CO) compared to echocardiography in newborn infants, and the inter-rater agreement of USCOM measurements. Methods: In a single-center study we prospectively evaluated neonates undergoing an echocardiographic evaluation. USCOM measurements of CO were obtained at the pulmonary and aortic valve by 2 physicians blinded to the echocardiographic results. All echocardiographic measurements were performed blinded to USCOM measurements. We first enrolled an ascertainment cohort which was subsequently validated in an independent new cohort. Agreement between echocardiography and USCOM methods was assessed by Bland-Altman analysis. Intra-class correlation coefficients (ICC) assessed the agreement between the 2 operators. The ascertainment cohort correction factors were applied in a second validation cohort and agreement of the calibrated measures evaluated with repeat Bland-Altman comparisons. Results: A total of 50 infants were enrolled in the initial cohort and 15 in the validation cohort. There was a high degree of correlation between the USCOM operators (ICC = 0.975). USCOM measurements of CO were significantly higher compared to echocardiography (left ventricular output bias 95 ± 52 mL/kg/min and right ventricular output bias 64 ± 30 mL/kg/min). There was no difference in the subgroup of infants with and without a ductus arteriosus. After the correction was applied to the validation cohort, there was no longer a significant difference between the measures. Conclusions: CO measured by USCOM consistently overestimated the results obtained from echocardiography. USCOM is not adequate to provide absolute estimates of CO. However, it may allow longitudinal hemodynamic assessment of sick neonates.</description><identifier>ISSN: 1661-7800</identifier><identifier>EISSN: 1661-7819</identifier><identifier>DOI: 10.1159/000501005</identifier><identifier>PMID: 31326967</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Cardiac output ; Health aspects ; Hemodynamic monitoring ; Infants (Newborn) ; Measurement ; Methods ; Original Paper ; Pediatric research</subject><ispartof>Neonatology (Basel, Switzerland), 2019-10, Vol.116 (3), p.260-268</ispartof><rights>2019 S. Karger AG, Basel</rights><rights>2019 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2019 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-5c92c849323d3ade170a49b0be9b2a8816ff5e38c620cde18ff3abb427fe02db3</citedby><cites>FETCH-LOGICAL-c432t-5c92c849323d3ade170a49b0be9b2a8816ff5e38c620cde18ff3abb427fe02db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31326967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fraga, María V.</creatorcontrib><creatorcontrib>Dysart, Kevin C.</creatorcontrib><creatorcontrib>Rintoul, Natalie</creatorcontrib><creatorcontrib>Chaudhary, Aasma S.</creatorcontrib><creatorcontrib>Ratcliffe, Sarah J.</creatorcontrib><creatorcontrib>Fedec, Anysia</creatorcontrib><creatorcontrib>Kren, Stephanie</creatorcontrib><creatorcontrib>Cohen, Meryl S.</creatorcontrib><creatorcontrib>Kirpalani, Haresh</creatorcontrib><title>Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants</title><title>Neonatology (Basel, Switzerland)</title><addtitle>Neonatology</addtitle><description>Objectives: We aimed to determine the accuracy and validity of the Ultrasonic Cardiac Output Monitor (USCOM) measurements of cardiac output (CO) compared to echocardiography in newborn infants, and the inter-rater agreement of USCOM measurements. Methods: In a single-center study we prospectively evaluated neonates undergoing an echocardiographic evaluation. USCOM measurements of CO were obtained at the pulmonary and aortic valve by 2 physicians blinded to the echocardiographic results. All echocardiographic measurements were performed blinded to USCOM measurements. We first enrolled an ascertainment cohort which was subsequently validated in an independent new cohort. Agreement between echocardiography and USCOM methods was assessed by Bland-Altman analysis. Intra-class correlation coefficients (ICC) assessed the agreement between the 2 operators. The ascertainment cohort correction factors were applied in a second validation cohort and agreement of the calibrated measures evaluated with repeat Bland-Altman comparisons. Results: A total of 50 infants were enrolled in the initial cohort and 15 in the validation cohort. There was a high degree of correlation between the USCOM operators (ICC = 0.975). USCOM measurements of CO were significantly higher compared to echocardiography (left ventricular output bias 95 ± 52 mL/kg/min and right ventricular output bias 64 ± 30 mL/kg/min). There was no difference in the subgroup of infants with and without a ductus arteriosus. After the correction was applied to the validation cohort, there was no longer a significant difference between the measures. Conclusions: CO measured by USCOM consistently overestimated the results obtained from echocardiography. USCOM is not adequate to provide absolute estimates of CO. However, it may allow longitudinal hemodynamic assessment of sick neonates.</description><subject>Cardiac output</subject><subject>Health aspects</subject><subject>Hemodynamic monitoring</subject><subject>Infants (Newborn)</subject><subject>Measurement</subject><subject>Methods</subject><subject>Original Paper</subject><subject>Pediatric research</subject><issn>1661-7800</issn><issn>1661-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpt0c1vFCEUAPCJ0dhaPXg3hsTE6GErHzPM4G2zabVJ7R50vRIGHrvoDKzAxPS_L5tdV2saEiDwe488XlW9JPickEZ8wBg3mJTpUXVKOCeztiPi8XGP8Un1LKUfBTQNp0-rE0YY5YK3p9W4UNE4pdFyytspoy-g0hRhBJ_RKjm_RnkDaDXkqFLwTqP_fTnMIX5Ec_RdDc6o7IJHX_NkbpHz6AZ-9yF6dOWt8jk9r55YNSR4cVjPqtXlxbfF59n18tPVYn490zWjedZoQXVXC0aZYcoAabGqRY97ED1VXUe4tQ2wTnOKdbnurGWq72vaWsDU9OyserfPu43h1wQpy9ElDcOgPIQpSUo5ES2pCS70zZ6u1QDSeRtKqXrH5Zyztm1FR7qizh9QZRgYnQ4erCvn9wLe_hOwATXkTQrDtPuedB--30MdQ0oRrNxGN6p4KwmWu-7KY3eLfX0oa-pHMEf5p51_i_mp4hriEdxcLPcp5NbYol49qA6v3AFWFLJk</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Fraga, María V.</creator><creator>Dysart, Kevin C.</creator><creator>Rintoul, Natalie</creator><creator>Chaudhary, Aasma S.</creator><creator>Ratcliffe, Sarah J.</creator><creator>Fedec, Anysia</creator><creator>Kren, Stephanie</creator><creator>Cohen, Meryl S.</creator><creator>Kirpalani, Haresh</creator><general>S. Karger AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants</title><author>Fraga, María V. ; Dysart, Kevin C. ; Rintoul, Natalie ; Chaudhary, Aasma S. ; Ratcliffe, Sarah J. ; Fedec, Anysia ; Kren, Stephanie ; Cohen, Meryl S. ; Kirpalani, Haresh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-5c92c849323d3ade170a49b0be9b2a8816ff5e38c620cde18ff3abb427fe02db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cardiac output</topic><topic>Health aspects</topic><topic>Hemodynamic monitoring</topic><topic>Infants (Newborn)</topic><topic>Measurement</topic><topic>Methods</topic><topic>Original Paper</topic><topic>Pediatric research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fraga, María V.</creatorcontrib><creatorcontrib>Dysart, Kevin C.</creatorcontrib><creatorcontrib>Rintoul, Natalie</creatorcontrib><creatorcontrib>Chaudhary, Aasma S.</creatorcontrib><creatorcontrib>Ratcliffe, Sarah J.</creatorcontrib><creatorcontrib>Fedec, Anysia</creatorcontrib><creatorcontrib>Kren, Stephanie</creatorcontrib><creatorcontrib>Cohen, Meryl S.</creatorcontrib><creatorcontrib>Kirpalani, Haresh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neonatology (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fraga, María V.</au><au>Dysart, Kevin C.</au><au>Rintoul, Natalie</au><au>Chaudhary, Aasma S.</au><au>Ratcliffe, Sarah J.</au><au>Fedec, Anysia</au><au>Kren, Stephanie</au><au>Cohen, Meryl S.</au><au>Kirpalani, Haresh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants</atitle><jtitle>Neonatology (Basel, Switzerland)</jtitle><addtitle>Neonatology</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>116</volume><issue>3</issue><spage>260</spage><epage>268</epage><pages>260-268</pages><issn>1661-7800</issn><eissn>1661-7819</eissn><abstract>Objectives: We aimed to determine the accuracy and validity of the Ultrasonic Cardiac Output Monitor (USCOM) measurements of cardiac output (CO) compared to echocardiography in newborn infants, and the inter-rater agreement of USCOM measurements. Methods: In a single-center study we prospectively evaluated neonates undergoing an echocardiographic evaluation. USCOM measurements of CO were obtained at the pulmonary and aortic valve by 2 physicians blinded to the echocardiographic results. All echocardiographic measurements were performed blinded to USCOM measurements. We first enrolled an ascertainment cohort which was subsequently validated in an independent new cohort. Agreement between echocardiography and USCOM methods was assessed by Bland-Altman analysis. Intra-class correlation coefficients (ICC) assessed the agreement between the 2 operators. The ascertainment cohort correction factors were applied in a second validation cohort and agreement of the calibrated measures evaluated with repeat Bland-Altman comparisons. Results: A total of 50 infants were enrolled in the initial cohort and 15 in the validation cohort. There was a high degree of correlation between the USCOM operators (ICC = 0.975). USCOM measurements of CO were significantly higher compared to echocardiography (left ventricular output bias 95 ± 52 mL/kg/min and right ventricular output bias 64 ± 30 mL/kg/min). There was no difference in the subgroup of infants with and without a ductus arteriosus. After the correction was applied to the validation cohort, there was no longer a significant difference between the measures. Conclusions: CO measured by USCOM consistently overestimated the results obtained from echocardiography. USCOM is not adequate to provide absolute estimates of CO. However, it may allow longitudinal hemodynamic assessment of sick neonates.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>31326967</pmid><doi>10.1159/000501005</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1661-7800
ispartof Neonatology (Basel, Switzerland), 2019-10, Vol.116 (3), p.260-268
issn 1661-7800
1661-7819
language eng
recordid cdi_pubmed_primary_31326967
source Karger Journals Complete; Alma/SFX Local Collection
subjects Cardiac output
Health aspects
Hemodynamic monitoring
Infants (Newborn)
Measurement
Methods
Original Paper
Pediatric research
title Cardiac Output Measurement Using the Ultrasonic Cardiac Output Monitor: A Validation Study in Newborn Infants
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A20%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiac%20Output%20Measurement%20Using%20the%20Ultrasonic%20Cardiac%20Output%20Monitor:%20A%20Validation%20Study%20in%20Newborn%20Infants&rft.jtitle=Neonatology%20(Basel,%20Switzerland)&rft.au=Fraga,%20Mar%C3%ADa%C2%A0V.&rft.date=2019-10-01&rft.volume=116&rft.issue=3&rft.spage=260&rft.epage=268&rft.pages=260-268&rft.issn=1661-7800&rft.eissn=1661-7819&rft_id=info:doi/10.1159/000501005&rft_dat=%3Cgale_pubme%3EA637779818%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2261971410&rft_id=info:pmid/31326967&rft_galeid=A637779818&rfr_iscdi=true