Disruption of Ca 2+ i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice

Plakophilin-2 (PKP2) is classically defined as a desmosomal protein. Mutations in PKP2 associate with most cases of gene-positive arrhythmogenic right ventricular cardiomyopathy (ARVC). A better understanding of PKP2 cardiac biology can help elucidate the mechanisms underlying arrhythmic and cardiom...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-07
Hauptverfasser:	Kim, Joon-Chul, Pérez-Hernández Duran, Marta, Alvarado, Francisco J, Maurya, Svetlana R, Montnach, Jerome, Yin, Yandong, Zhang, Mingliang, Lin, Xianming, Vasquez, Carolina, Heguy, Adriana, Liang, Feng-Xia, Woo, Sun-Hee, Morley, Gregory E, Rothenberg, Eli, Lundby, Alicia, Valdivia, Hector H, Cerrone, Marina, Delmar, Mario
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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