Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure
Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR). This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR...
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Veröffentlicht in: | The Annals of thoracic surgery 2020-01, Vol.109 (1), p.110-117 |
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creator | Jalava, Maina P. Laakso, Teemu Virtanen, Marko Niemelä, Matti Ahvenvaara, Tuomas Tauriainen, Tuomas Maaranen, Pasi Husso, Annastiina Kinnunen, Eeva-Maija Dahlbacka, Sebastian Jaakkola, Jussi Airaksinen, Juhani Anttila, Vesa Rosato, Stefano D’Errigo, Paola Savontaus, Mikko Laine, Mika Mäkikallio, Timo Valtola, Antti Raivio, Peter Eskola, Markku Biancari, Fausto |
description | Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR).
This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR or SAVR with a bioprothesis for aortic stenosis. We evaluated the outcome of patients with acute heart failure (AHF) within 60 days prior to TAVR or SAVR.
The prevalence of recent AHF was 11.4% (484 of 4241 patients) in the SAVR cohort and 11.3% (210 of 1855 patients) in the TAVR cohort. In the SAVR cohort, AHF was associated with lower 30-day survival (91.3% vs 97.0%; adjusted odds ratio 1.801, 95% confidence interval [CI] 1.125-2.882) and 5-year survival (64.0% vs 81.2%; adjusted hazard ratio 1.482, 95% CI 1.207-1.821). SAVR patients with AHF had higher risk of major bleeding, need of mechanical circulatory support, acute kidney injury, prolonged hospital stay, and composite end-point (30-day mortality, stroke and/or acute kidney injury). Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR.
Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. These findings suggest that aortic stenosis patients should be referred for invasive treatment before the development of clinically evident heart failure. |
doi_str_mv | 10.1016/j.athoracsur.2019.05.044 |
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This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR or SAVR with a bioprothesis for aortic stenosis. We evaluated the outcome of patients with acute heart failure (AHF) within 60 days prior to TAVR or SAVR.
The prevalence of recent AHF was 11.4% (484 of 4241 patients) in the SAVR cohort and 11.3% (210 of 1855 patients) in the TAVR cohort. In the SAVR cohort, AHF was associated with lower 30-day survival (91.3% vs 97.0%; adjusted odds ratio 1.801, 95% confidence interval [CI] 1.125-2.882) and 5-year survival (64.0% vs 81.2%; adjusted hazard ratio 1.482, 95% CI 1.207-1.821). SAVR patients with AHF had higher risk of major bleeding, need of mechanical circulatory support, acute kidney injury, prolonged hospital stay, and composite end-point (30-day mortality, stroke and/or acute kidney injury). Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR.
Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. These findings suggest that aortic stenosis patients should be referred for invasive treatment before the development of clinically evident heart failure.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2019.05.044</identifier><identifier>PMID: 31288017</identifier><language>eng</language><publisher>NEW YORK: Elsevier Inc</publisher><subject>Acute Disease ; Aged ; Aged, 80 and over ; Aortic Valve - surgery ; Aortic Valve Stenosis - complications ; Aortic Valve Stenosis - surgery ; Cardiac & Cardiovascular Systems ; Cardiovascular System & Cardiology ; Cohort Studies ; Female ; Heart Failure - complications ; Heart Valve Prosthesis Implantation - methods ; Humans ; Life Sciences & Biomedicine ; Male ; Respiratory System ; Retrospective Studies ; Science & Technology ; Surgery ; Time Factors ; Transcatheter Aortic Valve Replacement</subject><ispartof>The Annals of thoracic surgery, 2020-01, Vol.109 (1), p.110-117</ispartof><rights>2020 The Society of Thoracic Surgeons</rights><rights>Copyright © 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000502619500039</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c424t-11c253e993f9bd79506ccd9d92e782acdfc3879cb66942eac7b8070f84e160d3</citedby><cites>FETCH-LOGICAL-c424t-11c253e993f9bd79506ccd9d92e782acdfc3879cb66942eac7b8070f84e160d3</cites><orcidid>0000-0001-9674-0772 ; 0000-0001-5028-8186 ; 0000-0002-1708-711X ; 0000-0002-0193-568X ; 0000-0002-9956-4978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934,28257</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31288017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jalava, Maina P.</creatorcontrib><creatorcontrib>Laakso, Teemu</creatorcontrib><creatorcontrib>Virtanen, Marko</creatorcontrib><creatorcontrib>Niemelä, Matti</creatorcontrib><creatorcontrib>Ahvenvaara, Tuomas</creatorcontrib><creatorcontrib>Tauriainen, Tuomas</creatorcontrib><creatorcontrib>Maaranen, Pasi</creatorcontrib><creatorcontrib>Husso, Annastiina</creatorcontrib><creatorcontrib>Kinnunen, Eeva-Maija</creatorcontrib><creatorcontrib>Dahlbacka, Sebastian</creatorcontrib><creatorcontrib>Jaakkola, Jussi</creatorcontrib><creatorcontrib>Airaksinen, Juhani</creatorcontrib><creatorcontrib>Anttila, Vesa</creatorcontrib><creatorcontrib>Rosato, Stefano</creatorcontrib><creatorcontrib>D’Errigo, Paola</creatorcontrib><creatorcontrib>Savontaus, Mikko</creatorcontrib><creatorcontrib>Laine, Mika</creatorcontrib><creatorcontrib>Mäkikallio, Timo</creatorcontrib><creatorcontrib>Valtola, Antti</creatorcontrib><creatorcontrib>Raivio, Peter</creatorcontrib><creatorcontrib>Eskola, Markku</creatorcontrib><creatorcontrib>Biancari, Fausto</creatorcontrib><title>Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure</title><title>The Annals of thoracic surgery</title><addtitle>ANN THORAC SURG</addtitle><addtitle>Ann Thorac Surg</addtitle><description>Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR).
This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR or SAVR with a bioprothesis for aortic stenosis. We evaluated the outcome of patients with acute heart failure (AHF) within 60 days prior to TAVR or SAVR.
The prevalence of recent AHF was 11.4% (484 of 4241 patients) in the SAVR cohort and 11.3% (210 of 1855 patients) in the TAVR cohort. In the SAVR cohort, AHF was associated with lower 30-day survival (91.3% vs 97.0%; adjusted odds ratio 1.801, 95% confidence interval [CI] 1.125-2.882) and 5-year survival (64.0% vs 81.2%; adjusted hazard ratio 1.482, 95% CI 1.207-1.821). SAVR patients with AHF had higher risk of major bleeding, need of mechanical circulatory support, acute kidney injury, prolonged hospital stay, and composite end-point (30-day mortality, stroke and/or acute kidney injury). Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR.
Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. These findings suggest that aortic stenosis patients should be referred for invasive treatment before the development of clinically evident heart failure.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Valve - surgery</subject><subject>Aortic Valve Stenosis - complications</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular System & Cardiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Heart Failure - complications</subject><subject>Heart Valve Prosthesis Implantation - methods</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Respiratory System</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Transcatheter Aortic Valve Replacement</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkVFv0zAQxy0EYqXsKyA_IqEE24mT-LFUG5s0aQgq9mg55wtzlcbFdob49rhqtz0y-cH23f9_vvuZEMpZyRlvPm9Lk-59MBDnUArGVclkyer6FVlwKUXRCKlekwVjrCpq1coz8i7Gbb6KnH5Lziouuo7xdkH0JpgpQi6HCQM1k6U_5vDLgRnpyofkgP404wPS77gfDeAOp0TdRL-Z5PIx0juX7nMSDvEVzAnpFZqQ6KVx4xzwPXkzmDHi-Wlfks3lxWZ9Vdzcfr1er24KqEWdCs5ByAqVqgbV21ZJ1gBYZZXAthMG7ABV1yrom0bVAg20fcdaNnQ18obZakk-Hsvug_89Y0x65yLgOJoJ_Ry1EFLWbSXzWpLuKIXgYww46H1wOxP-as70ga7e6me6-kBXM6kz3Wz9cHpl7ndon4yPOLPg01HwB3s_RMiIAJ9kmb9kouF5uvwx6rmTl6jXLmXkflr7eUrZ-uVoxcz0wWHQJ7t1ASFp693_x_kHDXKx8g</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Jalava, Maina P.</creator><creator>Laakso, Teemu</creator><creator>Virtanen, Marko</creator><creator>Niemelä, Matti</creator><creator>Ahvenvaara, Tuomas</creator><creator>Tauriainen, Tuomas</creator><creator>Maaranen, Pasi</creator><creator>Husso, Annastiina</creator><creator>Kinnunen, Eeva-Maija</creator><creator>Dahlbacka, Sebastian</creator><creator>Jaakkola, Jussi</creator><creator>Airaksinen, Juhani</creator><creator>Anttila, Vesa</creator><creator>Rosato, Stefano</creator><creator>D’Errigo, Paola</creator><creator>Savontaus, Mikko</creator><creator>Laine, Mika</creator><creator>Mäkikallio, Timo</creator><creator>Valtola, Antti</creator><creator>Raivio, Peter</creator><creator>Eskola, Markku</creator><creator>Biancari, Fausto</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9674-0772</orcidid><orcidid>https://orcid.org/0000-0001-5028-8186</orcidid><orcidid>https://orcid.org/0000-0002-1708-711X</orcidid><orcidid>https://orcid.org/0000-0002-0193-568X</orcidid><orcidid>https://orcid.org/0000-0002-9956-4978</orcidid></search><sort><creationdate>202001</creationdate><title>Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure</title><author>Jalava, Maina P. ; Laakso, Teemu ; Virtanen, Marko ; Niemelä, Matti ; Ahvenvaara, Tuomas ; Tauriainen, Tuomas ; Maaranen, Pasi ; Husso, Annastiina ; Kinnunen, Eeva-Maija ; Dahlbacka, Sebastian ; Jaakkola, Jussi ; Airaksinen, Juhani ; Anttila, Vesa ; Rosato, Stefano ; D’Errigo, Paola ; Savontaus, Mikko ; Laine, Mika ; Mäkikallio, Timo ; Valtola, Antti ; Raivio, Peter ; Eskola, Markku ; Biancari, Fausto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-11c253e993f9bd79506ccd9d92e782acdfc3879cb66942eac7b8070f84e160d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Valve - surgery</topic><topic>Aortic Valve Stenosis - complications</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiovascular System & Cardiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Heart Failure - complications</topic><topic>Heart Valve Prosthesis Implantation - methods</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Respiratory System</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Transcatheter Aortic Valve Replacement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jalava, Maina P.</creatorcontrib><creatorcontrib>Laakso, Teemu</creatorcontrib><creatorcontrib>Virtanen, Marko</creatorcontrib><creatorcontrib>Niemelä, Matti</creatorcontrib><creatorcontrib>Ahvenvaara, Tuomas</creatorcontrib><creatorcontrib>Tauriainen, Tuomas</creatorcontrib><creatorcontrib>Maaranen, Pasi</creatorcontrib><creatorcontrib>Husso, Annastiina</creatorcontrib><creatorcontrib>Kinnunen, Eeva-Maija</creatorcontrib><creatorcontrib>Dahlbacka, Sebastian</creatorcontrib><creatorcontrib>Jaakkola, Jussi</creatorcontrib><creatorcontrib>Airaksinen, Juhani</creatorcontrib><creatorcontrib>Anttila, Vesa</creatorcontrib><creatorcontrib>Rosato, Stefano</creatorcontrib><creatorcontrib>D’Errigo, Paola</creatorcontrib><creatorcontrib>Savontaus, Mikko</creatorcontrib><creatorcontrib>Laine, Mika</creatorcontrib><creatorcontrib>Mäkikallio, Timo</creatorcontrib><creatorcontrib>Valtola, Antti</creatorcontrib><creatorcontrib>Raivio, Peter</creatorcontrib><creatorcontrib>Eskola, Markku</creatorcontrib><creatorcontrib>Biancari, Fausto</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jalava, Maina P.</au><au>Laakso, Teemu</au><au>Virtanen, Marko</au><au>Niemelä, Matti</au><au>Ahvenvaara, Tuomas</au><au>Tauriainen, Tuomas</au><au>Maaranen, Pasi</au><au>Husso, Annastiina</au><au>Kinnunen, Eeva-Maija</au><au>Dahlbacka, Sebastian</au><au>Jaakkola, Jussi</au><au>Airaksinen, Juhani</au><au>Anttila, Vesa</au><au>Rosato, Stefano</au><au>D’Errigo, Paola</au><au>Savontaus, Mikko</au><au>Laine, Mika</au><au>Mäkikallio, Timo</au><au>Valtola, Antti</au><au>Raivio, Peter</au><au>Eskola, Markku</au><au>Biancari, Fausto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure</atitle><jtitle>The Annals of thoracic surgery</jtitle><stitle>ANN THORAC SURG</stitle><addtitle>Ann Thorac Surg</addtitle><date>2020-01</date><risdate>2020</risdate><volume>109</volume><issue>1</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR).
This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR or SAVR with a bioprothesis for aortic stenosis. We evaluated the outcome of patients with acute heart failure (AHF) within 60 days prior to TAVR or SAVR.
The prevalence of recent AHF was 11.4% (484 of 4241 patients) in the SAVR cohort and 11.3% (210 of 1855 patients) in the TAVR cohort. In the SAVR cohort, AHF was associated with lower 30-day survival (91.3% vs 97.0%; adjusted odds ratio 1.801, 95% confidence interval [CI] 1.125-2.882) and 5-year survival (64.0% vs 81.2%; adjusted hazard ratio 1.482, 95% CI 1.207-1.821). SAVR patients with AHF had higher risk of major bleeding, need of mechanical circulatory support, acute kidney injury, prolonged hospital stay, and composite end-point (30-day mortality, stroke and/or acute kidney injury). Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR.
Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. These findings suggest that aortic stenosis patients should be referred for invasive treatment before the development of clinically evident heart failure.</abstract><cop>NEW YORK</cop><pub>Elsevier Inc</pub><pmid>31288017</pmid><doi>10.1016/j.athoracsur.2019.05.044</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9674-0772</orcidid><orcidid>https://orcid.org/0000-0001-5028-8186</orcidid><orcidid>https://orcid.org/0000-0002-1708-711X</orcidid><orcidid>https://orcid.org/0000-0002-0193-568X</orcidid><orcidid>https://orcid.org/0000-0002-9956-4978</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acute Disease Aged Aged, 80 and over Aortic Valve - surgery Aortic Valve Stenosis - complications Aortic Valve Stenosis - surgery Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Cohort Studies Female Heart Failure - complications Heart Valve Prosthesis Implantation - methods Humans Life Sciences & Biomedicine Male Respiratory System Retrospective Studies Science & Technology Surgery Time Factors Transcatheter Aortic Valve Replacement |
title | Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure |
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