Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure

Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR). This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR...

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Veröffentlicht in:The Annals of thoracic surgery 2020-01, Vol.109 (1), p.110-117
Hauptverfasser: Jalava, Maina P., Laakso, Teemu, Virtanen, Marko, Niemelä, Matti, Ahvenvaara, Tuomas, Tauriainen, Tuomas, Maaranen, Pasi, Husso, Annastiina, Kinnunen, Eeva-Maija, Dahlbacka, Sebastian, Jaakkola, Jussi, Airaksinen, Juhani, Anttila, Vesa, Rosato, Stefano, D’Errigo, Paola, Savontaus, Mikko, Laine, Mika, Mäkikallio, Timo, Valtola, Antti, Raivio, Peter, Eskola, Markku, Biancari, Fausto
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container_end_page 117
container_issue 1
container_start_page 110
container_title The Annals of thoracic surgery
container_volume 109
creator Jalava, Maina P.
Laakso, Teemu
Virtanen, Marko
Niemelä, Matti
Ahvenvaara, Tuomas
Tauriainen, Tuomas
Maaranen, Pasi
Husso, Annastiina
Kinnunen, Eeva-Maija
Dahlbacka, Sebastian
Jaakkola, Jussi
Airaksinen, Juhani
Anttila, Vesa
Rosato, Stefano
D’Errigo, Paola
Savontaus, Mikko
Laine, Mika
Mäkikallio, Timo
Valtola, Antti
Raivio, Peter
Eskola, Markku
Biancari, Fausto
description Patients with severe aortic stenosis and heart failure have poor prognosis, and their outcomes may be suboptimal even after transcatheter (TAVR) and surgical aortic valve replacement (SAVR). This is an analysis of the nationwide FinnValve registry, which included patients who underwent primary TAVR or SAVR with a bioprothesis for aortic stenosis. We evaluated the outcome of patients with acute heart failure (AHF) within 60 days prior to TAVR or SAVR. The prevalence of recent AHF was 11.4% (484 of 4241 patients) in the SAVR cohort and 11.3% (210 of 1855 patients) in the TAVR cohort. In the SAVR cohort, AHF was associated with lower 30-day survival (91.3% vs 97.0%; adjusted odds ratio 1.801, 95% confidence interval [CI] 1.125-2.882) and 5-year survival (64.0% vs 81.2%; adjusted hazard ratio 1.482, 95% CI 1.207-1.821). SAVR patients with AHF had higher risk of major bleeding, need of mechanical circulatory support, acute kidney injury, prolonged hospital stay, and composite end-point (30-day mortality, stroke and/or acute kidney injury). Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR. Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. These findings suggest that aortic stenosis patients should be referred for invasive treatment before the development of clinically evident heart failure.
doi_str_mv 10.1016/j.athoracsur.2019.05.044
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Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR. Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. 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Patients with AHF had a trend toward lower 30-day survival (crude rates 95.2% vs 97.9%; adjusted odds ratio 2.028, 95% CI 0.908-4.529) as well as significantly lower 5-year survival (crude rates 45.3% vs 58.5%; adjusted hazard ratio 1.530, 95% CI 1.185-1.976) also after TAVR. AHF increased the risk of acute kidney injury, prolonged hospital stay, and composite end-point after TAVR. Recent AHF is associated with increased risk of mortality and morbidity after SAVR and TAVR. 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source MEDLINE; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Acute Disease
Aged
Aged, 80 and over
Aortic Valve - surgery
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - surgery
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Cohort Studies
Female
Heart Failure - complications
Heart Valve Prosthesis Implantation - methods
Humans
Life Sciences & Biomedicine
Male
Respiratory System
Retrospective Studies
Science & Technology
Surgery
Time Factors
Transcatheter Aortic Valve Replacement
title Transcatheter and Surgical Aortic Valve Replacement in Patients With Recent Acute Heart Failure
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