1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2019-01, Vol.34 (1), p.1218-1225
Hauptverfasser:	Raingeval, Claire, Cala, Olivier, Brion, Béatrice, Le Borgne, Marc, Hubbard, Roderick Eliot, Krimm, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry binding mode Binding Sites Chemical Sciences Drug Discovery - methods fragment-based lead discovery Magnetic Resonance Spectroscopy - methods Medicinal Chemistry Proteins - chemistry Research Paper saturation transfer difference solvent-exposed WaterLOGSY
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