Hydrophilic modification on polyvinyl alcohol membrane by hyaluronic acid
PVA was dissolved in mixed solvent (DMSO and water) and followed by several freeze-thaw cycles in a mold to produce PVA membrane. Surface modification of PVA membranes by HA molecules was investigated to improve the hydrophilicity of the membrane surface thereby reducing adsorption of the proteins o...
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| Veröffentlicht in: | Biomedical materials (Bristol) 2019-08, Vol.14 (5), p.055009-055009 |
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| creator | Liu, Yan Hu, Huiyuan Yang, Xinlin Lv, Jing Zhou, Li Luo, Zhongkuan |
| description | PVA was dissolved in mixed solvent (DMSO and water) and followed by several freeze-thaw cycles in a mold to produce PVA membrane. Surface modification of PVA membranes by HA molecules was investigated to improve the hydrophilicity of the membrane surface thereby reducing adsorption of the proteins onto the membrane. The surface composition, water contact angle, optical and mechanical properties, surface morphology, cell compatibility and protein adhesion were systematically investigated. ATR-FTIR spectra, XPS, SEM and AFM indicated that PVA membranes were successfully modified by grafting of the HA. The modified membranes showed increased hydrophilicity and cytocompatibility, decreased surface roughness and mechanical properties, and suppressed cell and protein adhesion compared to the pristine membrane. In general, the achievement of the HA coating with anti-adhesive property can potentially be widely used on surface modification of artificial cornea and other biomedical implants. |
| doi_str_mv | 10.1088/1748-605X/ab3010 |
| format | Article |
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Surface modification of PVA membranes by HA molecules was investigated to improve the hydrophilicity of the membrane surface thereby reducing adsorption of the proteins onto the membrane. The surface composition, water contact angle, optical and mechanical properties, surface morphology, cell compatibility and protein adhesion were systematically investigated. ATR-FTIR spectra, XPS, SEM and AFM indicated that PVA membranes were successfully modified by grafting of the HA. The modified membranes showed increased hydrophilicity and cytocompatibility, decreased surface roughness and mechanical properties, and suppressed cell and protein adhesion compared to the pristine membrane. In general, the achievement of the HA coating with anti-adhesive property can potentially be widely used on surface modification of artificial cornea and other biomedical implants.</description><identifier>ISSN: 1748-605X</identifier><identifier>EISSN: 1748-605X</identifier><identifier>DOI: 10.1088/1748-605X/ab3010</identifier><identifier>PMID: 31284277</identifier><identifier>CODEN: BMBUCS</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>Adsorption ; antifouling material ; artificial cornea ; Biocompatible Materials - chemistry ; biomaterial ; Cell Adhesion ; Cell Proliferation ; Dimethyl Sulfoxide - chemistry ; Fibroblasts - cytology ; Humans ; hyaluronic acid ; Hyaluronic Acid - chemistry ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Materials Testing ; Membranes, Artificial ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; polyvinyl alcohol ; Polyvinyl Alcohol - chemistry ; Prostheses and Implants ; Proteins - chemistry ; Solvents ; Spectroscopy, Fourier Transform Infrared ; Stress, Mechanical ; Surface Properties ; Tensile Strength ; Water - chemistry ; X-Rays</subject><ispartof>Biomedical materials (Bristol), 2019-08, Vol.14 (5), p.055009-055009</ispartof><rights>2019 IOP Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-388a75672f386730f6d0bcfdedb23e34b384e15cec3225067ec6df42241ee9613</citedby><cites>FETCH-LOGICAL-c368t-388a75672f386730f6d0bcfdedb23e34b384e15cec3225067ec6df42241ee9613</cites><orcidid>0000-0001-9241-1824 ; 0000-0002-7082-270X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1748-605X/ab3010/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,780,784,27923,27924,53845,53892</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31284277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Hu, Huiyuan</creatorcontrib><creatorcontrib>Yang, Xinlin</creatorcontrib><creatorcontrib>Lv, Jing</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Luo, Zhongkuan</creatorcontrib><title>Hydrophilic modification on polyvinyl alcohol membrane by hyaluronic acid</title><title>Biomedical materials (Bristol)</title><addtitle>BMM</addtitle><addtitle>Biomed. Mater</addtitle><description>PVA was dissolved in mixed solvent (DMSO and water) and followed by several freeze-thaw cycles in a mold to produce PVA membrane. Surface modification of PVA membranes by HA molecules was investigated to improve the hydrophilicity of the membrane surface thereby reducing adsorption of the proteins onto the membrane. The surface composition, water contact angle, optical and mechanical properties, surface morphology, cell compatibility and protein adhesion were systematically investigated. ATR-FTIR spectra, XPS, SEM and AFM indicated that PVA membranes were successfully modified by grafting of the HA. The modified membranes showed increased hydrophilicity and cytocompatibility, decreased surface roughness and mechanical properties, and suppressed cell and protein adhesion compared to the pristine membrane. In general, the achievement of the HA coating with anti-adhesive property can potentially be widely used on surface modification of artificial cornea and other biomedical implants.</description><subject>Adsorption</subject><subject>antifouling material</subject><subject>artificial cornea</subject><subject>Biocompatible Materials - chemistry</subject><subject>biomaterial</subject><subject>Cell Adhesion</subject><subject>Cell Proliferation</subject><subject>Dimethyl Sulfoxide - chemistry</subject><subject>Fibroblasts - cytology</subject><subject>Humans</subject><subject>hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Kinetics</subject><subject>Materials Testing</subject><subject>Membranes, Artificial</subject><subject>Microscopy, Atomic Force</subject><subject>Microscopy, Electron, Scanning</subject><subject>polyvinyl alcohol</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Prostheses and Implants</subject><subject>Proteins - chemistry</subject><subject>Solvents</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Stress, Mechanical</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>Water - chemistry</subject><subject>X-Rays</subject><issn>1748-605X</issn><issn>1748-605X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAUx4Mobk7vnqQ3PViXn216lKFuMPCi4C2kScoy0qamq9D_3ozO4UEh8EL4fN7L-wJwjeADgpzPUU55mkH2MZclgQiegOnx6fTXfQIuum4LISsYKc7BhCDMKc7zKVgtBx18u7HOqqT22lZWyZ31TRJP693wZZvBJdIpv_EuqU1dBtmYpBySzSBdH3wTRamsvgRnlXSduTrUGXh_fnpbLNP168tq8bhOFcn4LiWcy5xlOa4Iz3ICq0zDUlXa6BITQ2hJODWIKaMIxgxmuVGZrijGFBlTZIjMwN3Ytw3-szfdTtS2U8a5-C3fdyJaNHoM04jCEVXBd10wlWiDrWUYBIJiH6DYJyT2CYkxwKjcHLr3ZW30UfhJLAK3I2B9K7a-D01cVpR1LRAVTEDGICxEq6tI3v9B_jv5GxHihx4</recordid><startdate>20190802</startdate><enddate>20190802</enddate><creator>Liu, Yan</creator><creator>Hu, Huiyuan</creator><creator>Yang, Xinlin</creator><creator>Lv, Jing</creator><creator>Zhou, Li</creator><creator>Luo, Zhongkuan</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9241-1824</orcidid><orcidid>https://orcid.org/0000-0002-7082-270X</orcidid></search><sort><creationdate>20190802</creationdate><title>Hydrophilic modification on polyvinyl alcohol membrane by hyaluronic acid</title><author>Liu, Yan ; Hu, Huiyuan ; Yang, Xinlin ; Lv, Jing ; Zhou, Li ; Luo, Zhongkuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-388a75672f386730f6d0bcfdedb23e34b384e15cec3225067ec6df42241ee9613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adsorption</topic><topic>antifouling material</topic><topic>artificial cornea</topic><topic>Biocompatible Materials - chemistry</topic><topic>biomaterial</topic><topic>Cell Adhesion</topic><topic>Cell Proliferation</topic><topic>Dimethyl Sulfoxide - chemistry</topic><topic>Fibroblasts - cytology</topic><topic>Humans</topic><topic>hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Kinetics</topic><topic>Materials Testing</topic><topic>Membranes, Artificial</topic><topic>Microscopy, Atomic Force</topic><topic>Microscopy, Electron, Scanning</topic><topic>polyvinyl alcohol</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Prostheses and Implants</topic><topic>Proteins - chemistry</topic><topic>Solvents</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Stress, Mechanical</topic><topic>Surface Properties</topic><topic>Tensile Strength</topic><topic>Water - chemistry</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Hu, Huiyuan</creatorcontrib><creatorcontrib>Yang, Xinlin</creatorcontrib><creatorcontrib>Lv, Jing</creatorcontrib><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Luo, Zhongkuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical materials (Bristol)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yan</au><au>Hu, Huiyuan</au><au>Yang, Xinlin</au><au>Lv, Jing</au><au>Zhou, Li</au><au>Luo, Zhongkuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrophilic modification on polyvinyl alcohol membrane by hyaluronic acid</atitle><jtitle>Biomedical materials (Bristol)</jtitle><stitle>BMM</stitle><addtitle>Biomed. Mater</addtitle><date>2019-08-02</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>055009</spage><epage>055009</epage><pages>055009-055009</pages><issn>1748-605X</issn><eissn>1748-605X</eissn><coden>BMBUCS</coden><abstract>PVA was dissolved in mixed solvent (DMSO and water) and followed by several freeze-thaw cycles in a mold to produce PVA membrane. Surface modification of PVA membranes by HA molecules was investigated to improve the hydrophilicity of the membrane surface thereby reducing adsorption of the proteins onto the membrane. The surface composition, water contact angle, optical and mechanical properties, surface morphology, cell compatibility and protein adhesion were systematically investigated. ATR-FTIR spectra, XPS, SEM and AFM indicated that PVA membranes were successfully modified by grafting of the HA. The modified membranes showed increased hydrophilicity and cytocompatibility, decreased surface roughness and mechanical properties, and suppressed cell and protein adhesion compared to the pristine membrane. In general, the achievement of the HA coating with anti-adhesive property can potentially be widely used on surface modification of artificial cornea and other biomedical implants.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>31284277</pmid><doi>10.1088/1748-605X/ab3010</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9241-1824</orcidid><orcidid>https://orcid.org/0000-0002-7082-270X</orcidid></addata></record> |
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| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Adsorption antifouling material artificial cornea Biocompatible Materials - chemistry biomaterial Cell Adhesion Cell Proliferation Dimethyl Sulfoxide - chemistry Fibroblasts - cytology Humans hyaluronic acid Hyaluronic Acid - chemistry Hydrophobic and Hydrophilic Interactions Kinetics Materials Testing Membranes, Artificial Microscopy, Atomic Force Microscopy, Electron, Scanning polyvinyl alcohol Polyvinyl Alcohol - chemistry Prostheses and Implants Proteins - chemistry Solvents Spectroscopy, Fourier Transform Infrared Stress, Mechanical Surface Properties Tensile Strength Water - chemistry X-Rays |
| title | Hydrophilic modification on polyvinyl alcohol membrane by hyaluronic acid |
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