Clinical scale synthesis of intrinsically radiolabeled and cyclic RGD peptide functionalized 198 Au nanoparticles for targeted cancer therapy

The emerging concept of intrinsically radiolabeled nanoparticles has the potential to transform the preclinical and clinical studies by improving the in vivo stability and demonstrating minimal alteration in the inherent pharmacokinetics of the nanoparticles. In this paper, a simple and efficient si...

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Veröffentlicht in:	Nuclear medicine and biology 2019-05, Vol.72-73, p.1
Hauptverfasser:	Chakravarty, Rubel, Chakraborty, Sudipta, Guleria, Apurav, Kumar, Chandan, Kunwar, Amit, Nair, K V Vimalnath, Sarma, Haladhar Dev, Dash, Ashutosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gold - chemistry Melanoma, Experimental - metabolism Melanoma, Experimental - radiotherapy Metal Nanoparticles - chemistry Mice Mice, Inbred C57BL Molecular Targeted Therapy Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacokinetics Peptides, Cyclic - pharmacology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Radiopharmaceuticals - pharmacology Tissue Distribution
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