Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia
Objectives: Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematological malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has...
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| Veröffentlicht in: | Hematology (Luxembourg) 2019-01, Vol.24 (1), p.487-491 |
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| creator | Ye, Jiaxin Luo, Daliang Yu, Jianhong Zhu, Sibo |
| description | Objectives: Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematological malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has been little studied.
Methods: As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway analysis using TCGA AML datasets.
Results: Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network.
Conclusion: Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML. |
| doi_str_mv | 10.1080/16078454.2019.1631506 |
| format | Article |
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Methods: As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway analysis using TCGA AML datasets.
Results: Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network.
Conclusion: Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML.</description><identifier>ISSN: 1607-8454</identifier><identifier>EISSN: 1607-8454</identifier><identifier>DOI: 10.1080/16078454.2019.1631506</identifier><identifier>PMID: 31210592</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acute myeloid leukemia ; Gene Expression Profiling ; Gene Expression Regulation, Leukemic ; Gene Regulatory Networks ; Humans ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - metabolism ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; miRNA-mRNA association analysis ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; RNA, Neoplasm - biosynthesis ; RNA, Neoplasm - genetics ; transcriptomic sequencing analysis</subject><ispartof>Hematology (Luxembourg), 2019-01, Vol.24 (1), p.487-491</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-5628c16146a5d8c2c3515ba96169e3f4fe7e68c5e6eeddfd624037188d7c50483</citedby><cites>FETCH-LOGICAL-c413t-5628c16146a5d8c2c3515ba96169e3f4fe7e68c5e6eeddfd624037188d7c50483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/16078454.2019.1631506$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/16078454.2019.1631506$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,27502,27924,27925,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31210592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ye, Jiaxin</creatorcontrib><creatorcontrib>Luo, Daliang</creatorcontrib><creatorcontrib>Yu, Jianhong</creatorcontrib><creatorcontrib>Zhu, Sibo</creatorcontrib><title>Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia</title><title>Hematology (Luxembourg)</title><addtitle>Hematology</addtitle><description>Objectives: Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematological malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has been little studied.
Methods: As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway analysis using TCGA AML datasets.
Results: Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network.
Conclusion: Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML.</description><subject>Acute myeloid leukemia</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Leukemic</subject><subject>Gene Regulatory Networks</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>MicroRNAs - biosynthesis</subject><subject>MicroRNAs - genetics</subject><subject>miRNA-mRNA association analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Neoplasm - biosynthesis</subject><subject>RNA, Neoplasm - genetics</subject><subject>transcriptomic sequencing analysis</subject><issn>1607-8454</issn><issn>1607-8454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqs_Qdmjl9ZMdpNNb0rxCwpeKh5DmsxKbHZTk11k_71b2oonTzPMPDMvPIRcAZ0ClfQWBC1lwYspozCbgsiBU3FERtv5ZLs4_tOfkfOUPilljJb0lJzlwIDyGRuR92XUTTLRbdpQY6Yb7fvkUuYsNq2rHKZsjX0W8aPzug0xDYjNGmy_Q1wPWJPdm67FrO7RB2czj90aa6cvyEmlfcLLfR2Tt8eH5fx5snh9epnfLyamgLydcMGkAQGF0NxKw0zOga_0TICYYV4VFZYopOEoEK2trGAFzUuQ0paG00LmY3Kz-7uJ4avD1KraJYPe6wZDlxRjBZPABdAB5TvUxJBSxEptoqt17BVQtXWqDk7V1qnaOx3urvcR3apG-3t1kDgAdzvANVWItR7UeKta3fsQq0GvcWmA_834AQ-GhnM</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Ye, Jiaxin</creator><creator>Luo, Daliang</creator><creator>Yu, Jianhong</creator><creator>Zhu, Sibo</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia</title><author>Ye, Jiaxin ; Luo, Daliang ; Yu, Jianhong ; Zhu, Sibo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-5628c16146a5d8c2c3515ba96169e3f4fe7e68c5e6eeddfd624037188d7c50483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute myeloid leukemia</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Leukemic</topic><topic>Gene Regulatory Networks</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - metabolism</topic><topic>MicroRNAs - biosynthesis</topic><topic>MicroRNAs - genetics</topic><topic>miRNA-mRNA association analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Neoplasm - biosynthesis</topic><topic>RNA, Neoplasm - genetics</topic><topic>transcriptomic sequencing analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ye, Jiaxin</creatorcontrib><creatorcontrib>Luo, Daliang</creatorcontrib><creatorcontrib>Yu, Jianhong</creatorcontrib><creatorcontrib>Zhu, Sibo</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hematology (Luxembourg)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ye, Jiaxin</au><au>Luo, Daliang</au><au>Yu, Jianhong</au><au>Zhu, Sibo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia</atitle><jtitle>Hematology (Luxembourg)</jtitle><addtitle>Hematology</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>24</volume><issue>1</issue><spage>487</spage><epage>491</epage><pages>487-491</pages><issn>1607-8454</issn><eissn>1607-8454</eissn><abstract>Objectives: Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematological malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has been little studied.
Methods: As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway analysis using TCGA AML datasets.
Results: Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network.
Conclusion: Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31210592</pmid><doi>10.1080/16078454.2019.1631506</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute myeloid leukemia Gene Expression Profiling Gene Expression Regulation, Leukemic Gene Regulatory Networks Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism MicroRNAs - biosynthesis MicroRNAs - genetics miRNA-mRNA association analysis RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics transcriptomic sequencing analysis |
| title | Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia |
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