Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1 H NMR-based metabolomics study
Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study,...
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| Veröffentlicht in: | Parasites & vectors 2019-06, Vol.12 (1), p.300 |
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| creator | Lin, Caigui Chen, Zhong Zhang, Lingqiang Wei, Zhiliang Cheng, Kian-Kai Liu, Yueyue Shen, Guiping Fan, Haining Dong, Jiyang |
| description | Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (
H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.
A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P |
| doi_str_mv | 10.1186/s13071-019-3554-0 |
| format | Article |
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H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.
A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P < 0.001) in the blood serum obtained from the HAE patients than it was in the healthy patient group.
The altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions.</description><identifier>EISSN: 1756-3305</identifier><identifier>DOI: 10.1186/s13071-019-3554-0</identifier><identifier>PMID: 31196218</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Amino Acids - metabolism ; Echinococcosis, Hepatic - blood ; Echinococcosis, Hepatic - metabolism ; Echinococcosis, Hepatic - urine ; Energy Metabolism ; Female ; Humans ; Liver - parasitology ; Liver - pathology ; Magnetic Resonance Spectroscopy ; Male ; Metabolome ; Middle Aged ; Multivariate Analysis ; Young Adult</subject><ispartof>Parasites & vectors, 2019-06, Vol.12 (1), p.300</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1064-6548</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31196218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Caigui</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Zhang, Lingqiang</creatorcontrib><creatorcontrib>Wei, Zhiliang</creatorcontrib><creatorcontrib>Cheng, Kian-Kai</creatorcontrib><creatorcontrib>Liu, Yueyue</creatorcontrib><creatorcontrib>Shen, Guiping</creatorcontrib><creatorcontrib>Fan, Haining</creatorcontrib><creatorcontrib>Dong, Jiyang</creatorcontrib><title>Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1 H NMR-based metabolomics study</title><title>Parasites & vectors</title><addtitle>Parasit Vectors</addtitle><description>Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (
H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.
A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P < 0.001) in the blood serum obtained from the HAE patients than it was in the healthy patient group.
The altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions.</description><subject>Adult</subject><subject>Amino Acids - metabolism</subject><subject>Echinococcosis, Hepatic - blood</subject><subject>Echinococcosis, Hepatic - metabolism</subject><subject>Echinococcosis, Hepatic - urine</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - parasitology</subject><subject>Liver - pathology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Metabolome</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Young Adult</subject><issn>1756-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjrtOAzEQRa1IiITAB6RB8wMGD8ZOlpaH0kCB0kde75CdaL22bC9S_h4KUlPdUxwdXSFWqO4QN_a-oFZrlAobqY15lGomFrg2VmqtzFxclXJUyqrG2Esx14iNfcDNQoQX8px6yjweoPYEgapr48AeEuU65dZVjiPwCD2lX_bghm-Kg8tAvucx-uh9LFyewAHCFj7eP2XrCnXnVAzsC5Q6dadrcfHlhkI3f7sUt2-vu-etTFMbqNunzMHl0_78T_8r_AD1CEwo</recordid><startdate>20190613</startdate><enddate>20190613</enddate><creator>Lin, Caigui</creator><creator>Chen, Zhong</creator><creator>Zhang, Lingqiang</creator><creator>Wei, Zhiliang</creator><creator>Cheng, Kian-Kai</creator><creator>Liu, Yueyue</creator><creator>Shen, Guiping</creator><creator>Fan, Haining</creator><creator>Dong, Jiyang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-1064-6548</orcidid></search><sort><creationdate>20190613</creationdate><title>Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1 H NMR-based metabolomics study</title><author>Lin, Caigui ; Chen, Zhong ; Zhang, Lingqiang ; Wei, Zhiliang ; Cheng, Kian-Kai ; Liu, Yueyue ; Shen, Guiping ; Fan, Haining ; Dong, Jiyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_311962183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Amino Acids - metabolism</topic><topic>Echinococcosis, Hepatic - blood</topic><topic>Echinococcosis, Hepatic - metabolism</topic><topic>Echinococcosis, Hepatic - urine</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - parasitology</topic><topic>Liver - pathology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Metabolome</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Caigui</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Zhang, Lingqiang</creatorcontrib><creatorcontrib>Wei, Zhiliang</creatorcontrib><creatorcontrib>Cheng, Kian-Kai</creatorcontrib><creatorcontrib>Liu, Yueyue</creatorcontrib><creatorcontrib>Shen, Guiping</creatorcontrib><creatorcontrib>Fan, Haining</creatorcontrib><creatorcontrib>Dong, Jiyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Parasites & vectors</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Caigui</au><au>Chen, Zhong</au><au>Zhang, Lingqiang</au><au>Wei, Zhiliang</au><au>Cheng, Kian-Kai</au><au>Liu, Yueyue</au><au>Shen, Guiping</au><au>Fan, Haining</au><au>Dong, Jiyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1 H NMR-based metabolomics study</atitle><jtitle>Parasites & vectors</jtitle><addtitle>Parasit Vectors</addtitle><date>2019-06-13</date><risdate>2019</risdate><volume>12</volume><issue>1</issue><spage>300</spage><pages>300-</pages><eissn>1756-3305</eissn><abstract>Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (
H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.
A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P < 0.001) in the blood serum obtained from the HAE patients than it was in the healthy patient group.
The altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions.</abstract><cop>England</cop><pmid>31196218</pmid><doi>10.1186/s13071-019-3554-0</doi><orcidid>https://orcid.org/0000-0002-1064-6548</orcidid></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | Adult Amino Acids - metabolism Echinococcosis, Hepatic - blood Echinococcosis, Hepatic - metabolism Echinococcosis, Hepatic - urine Energy Metabolism Female Humans Liver - parasitology Liver - pathology Magnetic Resonance Spectroscopy Male Metabolome Middle Aged Multivariate Analysis Young Adult |
| title | Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1 H NMR-based metabolomics study |
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