Aurora kinase B-phosphorylated HP1α functions in chromosomal instability

Heterochromatin Protein 1 α (HP1α) associates with members of the chromosome passenger complex (CPC) during mitosis, at centromeres where it is required for full Aurora Kinase B (AURKB) activity. Conversely, recent reports have identified AURKB as the major kinase responsible for phosphorylation of...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2019-06, Vol.18 (12), p.1407-1421
Hauptverfasser:	Williams, Monique M., Mathison, Angela J., Christensen, Trent, Greipp, Patricia T., Knutson, Darlene L., Klee, Eric W., Zimmermann, Michael T., Iovanna, Juan, Lomberk, Gwen A., Urrutia, Raul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora Kinase Aurora Kinase B - antagonists & inhibitors Aurora Kinase B - metabolism CBX5 Cellular Biology Chromobox Protein Homolog 5 Chromosomal Instability Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Aberrations HeLa Cells Heterochromatin - metabolism HP1α Humans Kinetochores - metabolism Life Sciences Mice Mice, Inbred C57BL Mitosis Phosphorylation Phosphoserine - metabolism Protein Binding Protein Kinase Inhibitors - pharmacology Research Paper
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