Stereoselective covalent binding of enantiomers of anti-benzo[a]pyrene diol epoxide to DNA as probed by optical detection of magnetic resonance
Phosphorescence and optical detection of magnetic resonance measurements applied to the covalent adducts of (+)- and (-)-anti-benzo[a]pyrene with DNA show a marked red shift of the pyrenyl phosphorescence and a lowering of the zero field splitting parameters of the (-) adduct, relative to the (+) ad...
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| Veröffentlicht in: | Biochemistry (Easton) 1987-05, Vol.26 (9), p.2638-2641 |
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| container_end_page | 2641 |
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| container_issue | 9 |
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| container_title | Biochemistry (Easton) |
| container_volume | 26 |
| creator | KOLUBAYEV, V BRENNER, H. C GEACINTOV, N. E |
| description | Phosphorescence and optical detection of magnetic resonance measurements applied to the covalent adducts of (+)- and (-)-anti-benzo[a]pyrene with DNA show a marked red shift of the pyrenyl phosphorescence and a lowering of the zero field splitting parameters of the (-) adduct, relative to the (+) adduct and the (solvent-exposed) benzo[a]pyrene tetraol. These results are consistent with a predominance of quasi-intercalative sites in the (-) adduct and external, solvent-exposed sites in the (+) adduct. |
| doi_str_mv | 10.1021/bi00383a035 |
| format | Article |
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These results are consistent with a predominance of quasi-intercalative sites in the (-) adduct and external, solvent-exposed sites in the (+) adduct.</description><subject>7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Dihydroxydihydrobenzopyrenes</subject><subject>DNA</subject><subject>DNA Adducts</subject><subject>Luminescent Measurements</subject><subject>Magnetics</subject><subject>Medical sciences</subject><subject>Nucleic Acid Denaturation</subject><subject>Stereoisomerism</subject><subject>Tumors</subject><issn>0006-2960</issn><issn>1520-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQtBColMKJM5IPXAN2HCfxsSrlIVVwAE4IVY69qYwSO7JNRfkJfhlHVJxWszOamV2Ezim5oiSn140hhNVMEsYP0JTynGSFEPwQTQkhZZaLkhyjkxA-EixIVUzQhFFKOcun6Oc5ggcXoAMVzRawclvZgY24MVYbu8GuxWCljcb14MMIR5A1YL_dm3wfdh4sYG1ch2FwX0YDjg7fPM6xDHjwrgGNmx12QzRKdlhDHJOcHZ16ubGQ9thDcClEwSk6amUX4Gw_Z-j1dvmyuM9WT3cPi_kqG3LGYwYs16BqKbVQpOKq0CRdLHRZFpxJkROmRFu1ALwWRHFWKZBc1FrUQKVSFZuhiz_f4bPpQa8Hb3rpd-v9YxJ_uedlSLVbn8qZ8C-rkoZWgv0CFpZ0wA</recordid><startdate>19870505</startdate><enddate>19870505</enddate><creator>KOLUBAYEV, V</creator><creator>BRENNER, H. 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These results are consistent with a predominance of quasi-intercalative sites in the (-) adduct and external, solvent-exposed sites in the (+) adduct.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>3111532</pmid><doi>10.1021/bi00383a035</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2960 |
| ispartof | Biochemistry (Easton), 1987-05, Vol.26 (9), p.2638-2641 |
| issn | 0006-2960 1520-4995 |
| language | eng |
| recordid | cdi_pubmed_primary_3111532 |
| source | MEDLINE; ACS Publications |
| subjects | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Dihydroxydihydrobenzopyrenes DNA DNA Adducts Luminescent Measurements Magnetics Medical sciences Nucleic Acid Denaturation Stereoisomerism Tumors |
| title | Stereoselective covalent binding of enantiomers of anti-benzo[a]pyrene diol epoxide to DNA as probed by optical detection of magnetic resonance |
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