Metabolic Activation of Phenacetin and Phenetidine by Several Forms of Cytochrome P-450 Purified from Liver Microsomes of Rats and Hamsters

Metabolic activation of phenacetin by liver microsomes proceeds via both phenetidine and N-hydroxyphenacetin to direct-acting mutagens, i.e., N-hydroxyphenetidine and p-nitrosophenetole. Five different molecular species of cytochrome P-450 have been purified from liver microsomes of drug-pretreated...

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