Copper-catalyzed oxidative amination of methanol to access quinazolines

Copper-catalyzed oxidative amination of methanol to access quinazolines

A novel method for the copper-catalyzed oxidative amination of 2′-aminoarylketones with methanol as a C1 carbon source and ammonium acetate as an amine source to construct quinazolines was established in a one-pot manner. The reaction conditions are straightforward and highly atom economic to delive...

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Veröffentlicht in:Organic & biomolecular chemistry 2019-05, Vol.17 (19), p.4774-4782
Hauptverfasser: Satish, Gandhesiri, Polu, Ashok, Kota, Laxman, Ilangovan, Andivelu
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container_title Organic & biomolecular chemistry
container_volume 17
creator Satish, Gandhesiri
Polu, Ashok
Kota, Laxman
Ilangovan, Andivelu
description A novel method for the copper-catalyzed oxidative amination of 2′-aminoarylketones with methanol as a C1 carbon source and ammonium acetate as an amine source to construct quinazolines was established in a one-pot manner. The reaction conditions are straightforward and highly atom economic to deliver the corresponding quinazolines in high yields with wide functional group tolerance. Importantly, the present method is applicable on a multigram scale and its synthetic utility is demonstrated by synthesizing quazodine, a muscle-relaxing drug in high yields. A novel method for the copper-catalyzed oxidative amination of 2′-aminoarylketones with methanol as a C1 carbon source and ammonium acetate as an amine source to construct quinazolines was established in a one-pot manner.
doi_str_mv 10.1039/c9ob00392d
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title Copper-catalyzed oxidative amination of methanol to access quinazolines
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