Modulation of drug-metabolizing enzymes and transporters under hypoxia environment

Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism....

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Veröffentlicht in:	Sheng li hsüeh pao 2019-04, Vol.71 (2), p.336
Hauptverfasser:	Min, Qiong, Feng, Shi-Lan, Lu, Hui, Li, Wen-Bin, Wang, Chang, Zhang, Juan-Hong, Wang, Rong
Format:	Artikel
Sprache:	chi
Schlagworte:	Cell Hypoxia Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - physiology Membrane Transport Proteins - physiology MicroRNAs - physiology Pharmaceutical Preparations - metabolism
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