Imbalance of Ly-6C hi and Ly-6C lo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ

Inflammation in response to oxygen exposure is a major contributing factor in neonatal lung injury leading to bronchopulmonary dysplasia. Although increased levels of proinflammatory cytokines are seen in airway samples and blood from bronchopulmonary dysplasia patients, the innate immune responses...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-05, Vol.202 (9), p.2772
Hauptverfasser:	Eldredge, Laurie C, Creasy, Rane S, Tanaka, Shigeru, Lai, Jen-Feng, Ziegler, Steven F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - immunology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology Hyperoxia - immunology Hyperoxia - pathology Interferon-gamma - immunology Interferon-gamma - pharmacology Lung Injury - immunology Lung Injury - pathology Macrophages - immunology Macrophages - pathology Matrix Metalloproteinase 9 - immunology Mice Monocytes - immunology Monocytes - pathology
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