Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Mitochondrial Ca uniporter (MCU)-mediated Ca uptake promotes the buildup of reducing equivalents that fuel oxidative phosphorylation for cellular metabolism. Although MCU modulates mitochondrial bioenergetics, its function in energy homeostasis in vivo remains elusive. Here we demonstrate that delet...

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Veröffentlicht in:	Cell reports (Cambridge) 2019-03, Vol.26 (13), p.3709
Hauptverfasser:	Tomar, Dhanendra, Jaña, Fabián, Dong, Zhiwei, Quinn, 3rd, William J, Jadiya, Pooja, Breves, Sarah L, Daw, Cassidy C, Srikantan, Subramanya, Shanmughapriya, Santhanam, Nemani, Neeharika, Carvalho, Edmund, Tripathi, Aparna, Worth, Alison M, Zhang, Xueqian, Razmpour, Roshanak, Seelam, Ajay, Rhode, Stephen, Mehta, Anuj V, Murray, Michael, Slade, Daniel, Ramirez, Servio H, Mishra, Prashant, Gerhard, Glenn S, Caplan, Jeffrey, Norton, Luke, Sharma, Kumar, Rajan, Sudarsan, Balciunas, Darius, Wijesinghe, Dayanjan S, Ahima, Rexford S, Baur, Joseph A, Madesh, Muniswamy
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinase Kinases Animals Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Cells, Cultured Female Hep G2 Cells Hepatocytes - metabolism Humans Lipid Metabolism Male Mice Mice, Inbred C57BL Mitochondria, Liver - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Phosphoprotein Phosphatases - metabolism Protein Kinases - metabolism Zebrafish
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