Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine

Background: Rikkunshito has been used to treat gastrointestinal (GI) disorders. The purpose of this study was to investigate the effects of Rikkunshito, a traditional Japanese herbal medicine, on the pacemaker potentials of interstitial cells of Cajal (ICCs) from the small intestines of mice. Method...

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Veröffentlicht in:	Digestion 2020-05, Vol.101 (3), p.227-238
Hauptverfasser:	Kim, Jeong Nam, Nam, Joo Hyun, Lee, Jong Rok, Kim, Sang Chan, Kwon, Young Kyu, Kim, Byung Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Gastrointestinal Motility - drug effects Gastrointestinal Motility - physiology Interstitial Cells of Cajal - drug effects Interstitial Cells of Cajal - physiology Intestine, Small - cytology Intestine, Small - physiology Membrane Potentials - drug effects Mice Patch-Clamp Techniques Primary Cell Culture Receptors, Ghrelin - metabolism Research Article Signal Transduction - drug effects
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