Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro
Metal-semiconductor core-shell type Pd@SiO nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO core shell nanoparticles were...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2019-06, Vol.26, p.79 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | Dhanalekshmi, K I Sangeetha, K Meena, K S Magesan, P Manikandan, A Jayamoorthy, K |
| description | Metal-semiconductor core-shell type Pd@SiO
nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO
core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO
NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO
supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity. |
| doi_str_mv | 10.1016/j.pdpdt.2019.03.008 |
| format | Article |
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nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO
core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO
NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO
supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.</description><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2019.03.008</identifier><identifier>PMID: 30862470</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Cell Survival ; DNA - chemistry ; DNA - metabolism ; HeLa Cells - drug effects ; Humans ; In Vitro Techniques ; Metal Nanoparticles - chemistry ; Photochemotherapy - methods ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Protein Binding - drug effects ; Surface Properties</subject><ispartof>Photodiagnosis and photodynamic therapy, 2019-06, Vol.26, p.79</ispartof><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30862470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhanalekshmi, K I</creatorcontrib><creatorcontrib>Sangeetha, K</creatorcontrib><creatorcontrib>Meena, K S</creatorcontrib><creatorcontrib>Magesan, P</creatorcontrib><creatorcontrib>Manikandan, A</creatorcontrib><creatorcontrib>Jayamoorthy, K</creatorcontrib><title>Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>Metal-semiconductor core-shell type Pd@SiO
nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO
core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO
NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO
supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.</description><subject>Cell Survival</subject><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>HeLa Cells - drug effects</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Protein Binding - drug effects</subject><subject>Surface Properties</subject><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j91KwzAYQIMgbk6fQJC8QOuXnzbJnWM6FYYbuDsvRpqkLqNNS5MJfXsL6tW5ORw4CN0RyAmQ8uGU97a3KadAVA4sB5AXaE6kYBkplJih6xhPAIwr4FdoxkCWlAuYo8_dsUudHYNuvcHaJP_t04h1sPjpfYkrH6wPXzims_Uu4q7GO_v44beYYtMNLotH1zQ46ND1ekjeNJPkA54iQ3eDLmvdRHf7xwXar5_3q9dss315Wy03Wa9YyqRRNRUEqATJGSkJsYxKxkoHhSKm4kJyoQsnjCyNE4WGgjtNlea2qMwkLtD9b7Y_V62zh37wrR7Gw_8k-wGsTFLQ</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Dhanalekshmi, K I</creator><creator>Sangeetha, K</creator><creator>Meena, K S</creator><creator>Magesan, P</creator><creator>Manikandan, A</creator><creator>Jayamoorthy, K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201906</creationdate><title>Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro</title><author>Dhanalekshmi, K I ; Sangeetha, K ; Meena, K S ; Magesan, P ; Manikandan, A ; Jayamoorthy, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-8c9f27102808431611d328336e0591cb47847a5e7c86ce75a054ea29a4d5bc833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cell Survival</topic><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>HeLa Cells - drug effects</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Protein Binding - drug effects</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhanalekshmi, K I</creatorcontrib><creatorcontrib>Sangeetha, K</creatorcontrib><creatorcontrib>Meena, K S</creatorcontrib><creatorcontrib>Magesan, P</creatorcontrib><creatorcontrib>Manikandan, A</creatorcontrib><creatorcontrib>Jayamoorthy, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhanalekshmi, K I</au><au>Sangeetha, K</au><au>Meena, K S</au><au>Magesan, P</au><au>Manikandan, A</au><au>Jayamoorthy, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2019-06</date><risdate>2019</risdate><volume>26</volume><spage>79</spage><pages>79-</pages><eissn>1873-1597</eissn><abstract>Metal-semiconductor core-shell type Pd@SiO
nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO
core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO
NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO
supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.</abstract><cop>Netherlands</cop><pmid>30862470</pmid><doi>10.1016/j.pdpdt.2019.03.008</doi></addata></record> |
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| identifier | EISSN: 1873-1597 |
| ispartof | Photodiagnosis and photodynamic therapy, 2019-06, Vol.26, p.79 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cell Survival DNA - chemistry DNA - metabolism HeLa Cells - drug effects Humans In Vitro Techniques Metal Nanoparticles - chemistry Photochemotherapy - methods Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Protein Binding - drug effects Surface Properties |
| title | Photodynamic activity and DNA binding studies of Pd@SiO 2 core-shell nanoparticles in vitro |
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