The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA receptors have analgesic benefit in addition to efficacy in anxiety disorders. However, the utility of GABA receptor PAMs as analgesics is compromised by the central nervous system side effects of non-selective potentiato...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2019-05, Vol.180, p.22
Hauptverfasser:	Witkin, J M, Cerne, R, Davis, P G, Freeman, K B, do Carmo, J M, Rowlett, J K, Methuku, K R, Okun, A, Gleason, S D, Li, X, Krambis, M J, Poe, M, Li, G, Schkeryantz, J M, Jahan, R, Yang, L, Guo, W, Golani, L K, Anderson, W H, Catlow, J T, Jones, T M, Porreca, F, Smith, J L, Knopp, K L, Cook, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Anesthesia - pharmacology Administration, Oral Alprazolam - administration & dosage Alprazolam - pharmacology Analgesics - administration & dosage Analgesics - metabolism Analgesics - pharmacology Analgesics - therapeutic use Animals Behavior, Animal - drug effects Diazepam - pharmacology Dose-Response Relationship, Drug Drug Synergism Formaldehyde - pharmacology GABA Modulators - administration & dosage GABA Modulators - pharmacology Ligation Male Neuralgia - drug therapy Oxazoles - administration & dosage Oxazoles - metabolism Oxazoles - pharmacology Oxazoles - therapeutic use Pain Measurement Rats Rats, Sprague-Dawley Receptors, GABA-A - metabolism Spinal Nerves - surgery
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