Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats. Alleviation by quercetin
The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During...
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| Veröffentlicht in: | General physiology and biophysics 2019-01, Vol.38 (2), p.123-134 |
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| container_title | General physiology and biophysics |
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| creator | Soudani, Nejla Chaâbane, Mariem Ghorbel, Imen Elwej, Awatef Boudawara, Tahia Zeghal, Najiba |
| description | The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During the experimental period (15 days), glyphosate (50 mg/kg b.w.) was administered every two days by intraperitoneal way while quercetin (20 mg/kg b.w./day) was administered daily by gavage. Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants. Plasma biomarkers of hepatotoxicity (AST, ALT, ALP, γ-GT, albumin) were also altered. Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats' liver. Quercetin supplementation to glyphosate-treated rats markedly ameliorated all the parameters indicated above as well as the liver histoarchitecture. Therefore, quercetin might have beneficial effects against glyphosate-induced hepatotoxicity in rats. |
| doi_str_mv | 10.4149/gpb_2018043 |
| format | Article |
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Alleviation by quercetin</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Soudani, Nejla ; Chaâbane, Mariem ; Ghorbel, Imen ; Elwej, Awatef ; Boudawara, Tahia ; Zeghal, Najiba</creator><creatorcontrib>Soudani, Nejla ; Chaâbane, Mariem ; Ghorbel, Imen ; Elwej, Awatef ; Boudawara, Tahia ; Zeghal, Najiba</creatorcontrib><description>The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During the experimental period (15 days), glyphosate (50 mg/kg b.w.) was administered every two days by intraperitoneal way while quercetin (20 mg/kg b.w./day) was administered daily by gavage. Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants. Plasma biomarkers of hepatotoxicity (AST, ALT, ALP, γ-GT, albumin) were also altered. Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats' liver. Quercetin supplementation to glyphosate-treated rats markedly ameliorated all the parameters indicated above as well as the liver histoarchitecture. Therefore, quercetin might have beneficial effects against glyphosate-induced hepatotoxicity in rats.</description><identifier>ISSN: 0231-5882</identifier><identifier>ISSN: 1338-4325</identifier><identifier>EISSN: 1338-4325</identifier><identifier>DOI: 10.4149/gpb_2018043</identifier><identifier>PMID: 30821249</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Animals ; Antioxidants ; Glycine - analogs & derivatives ; Glycine - physiology ; Glyphosate ; Liver ; Metallothionein - drug effects ; Metallothionein - metabolism ; Oxidation-Reduction ; Oxidative Stress ; Quercetin - pharmacology ; Random Allocation ; Rats ; Rats, Wistar ; Superoxide Dismutase</subject><ispartof>General physiology and biophysics, 2019-01, Vol.38 (2), p.123-134</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-9bbdedc293090f860071d80bb1a6ae9ba208b5d42215fb6bb34687895a6755c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30821249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soudani, Nejla</creatorcontrib><creatorcontrib>Chaâbane, Mariem</creatorcontrib><creatorcontrib>Ghorbel, Imen</creatorcontrib><creatorcontrib>Elwej, Awatef</creatorcontrib><creatorcontrib>Boudawara, Tahia</creatorcontrib><creatorcontrib>Zeghal, Najiba</creatorcontrib><title>Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats. Alleviation by quercetin</title><title>General physiology and biophysics</title><addtitle>Gen Physiol Biophys</addtitle><description>The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During the experimental period (15 days), glyphosate (50 mg/kg b.w.) was administered every two days by intraperitoneal way while quercetin (20 mg/kg b.w./day) was administered daily by gavage. Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants. Plasma biomarkers of hepatotoxicity (AST, ALT, ALP, γ-GT, albumin) were also altered. Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats' liver. Quercetin supplementation to glyphosate-treated rats markedly ameliorated all the parameters indicated above as well as the liver histoarchitecture. Therefore, quercetin might have beneficial effects against glyphosate-induced hepatotoxicity in rats.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - physiology</subject><subject>Glyphosate</subject><subject>Liver</subject><subject>Metallothionein - drug effects</subject><subject>Metallothionein - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Quercetin - pharmacology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase</subject><issn>0231-5882</issn><issn>1338-4325</issn><issn>1338-4325</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkL1OwzAURi0EolXpxI68oxT_xKk9VhWUSJVYukd2fNMGuUmwnap9Cx6ZlALiLnc4R99wELqnZJbSVD1tO1MwQiVJ-RUaU85lknImrtGYME4TISUboWkI72Q4MVeMkVs04kQyylI1Rp8rd-p2bdARsK2D77sYsAfbHnGIOvYB68bivks8bHs3WAHvIWrn2rir2wbqBuffSp7jLTQDhmPnIYQB4gHGHWBXH8DjtsLa9i5ir2OY4YVzcKh1PHvmhD968CXEurlDN5V2AaY_f4I2L8-b5Wuyflvly8U6KTnLYqKMsWBLpjhRpJIZIXNqJTGG6kyDMpoRaYRNGaOiMpkxPM3kXCqhs7kQJZ-gx8ts6dsQPFRF5-u99qeCkuJctvhXdrAfLnbXmz3YP_e3I_8CQzB2-g</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Soudani, Nejla</creator><creator>Chaâbane, Mariem</creator><creator>Ghorbel, Imen</creator><creator>Elwej, Awatef</creator><creator>Boudawara, Tahia</creator><creator>Zeghal, Najiba</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190101</creationdate><title>Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats. 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Alleviation by quercetin</atitle><jtitle>General physiology and biophysics</jtitle><addtitle>Gen Physiol Biophys</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>38</volume><issue>2</issue><spage>123</spage><epage>134</epage><pages>123-134</pages><issn>0231-5882</issn><issn>1338-4325</issn><eissn>1338-4325</eissn><abstract>The present work evaluated the possible protective effects of quercetin against glyphosate-induced hepatotoxicity in adult rats. Rats were randomly divided into three groups: a control group (C), a glyphosate-treated group (Gly) and a group treated with both glyphosate and quercetin (Gly+QE). During the experimental period (15 days), glyphosate (50 mg/kg b.w.) was administered every two days by intraperitoneal way while quercetin (20 mg/kg b.w./day) was administered daily by gavage. Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants. Plasma biomarkers of hepatotoxicity (AST, ALT, ALP, γ-GT, albumin) were also altered. Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats' liver. Quercetin supplementation to glyphosate-treated rats markedly ameliorated all the parameters indicated above as well as the liver histoarchitecture. Therefore, quercetin might have beneficial effects against glyphosate-induced hepatotoxicity in rats.</abstract><cop>Slovakia</cop><pmid>30821249</pmid><doi>10.4149/gpb_2018043</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | General physiology and biophysics, 2019-01, Vol.38 (2), p.123-134 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antioxidants Glycine - analogs & derivatives Glycine - physiology Glyphosate Liver Metallothionein - drug effects Metallothionein - metabolism Oxidation-Reduction Oxidative Stress Quercetin - pharmacology Random Allocation Rats Rats, Wistar Superoxide Dismutase |
| title | Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats. Alleviation by quercetin |
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