Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18 F and 64 Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized wit...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (29), p.4162-4165
Hauptverfasser:	Kuan, Hu, Masayuki, Hanyu, Xie, Lin, Zhang, Yiding, Kotaro, Nagatsu, Hisashi, Suzuki, Zhang, Ming-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Imaging In vivo methods and tests Peptides Pharmacology Positron emission Radioactive tracers Radiochemistry Tomography
Online-Zugang:	Volltext
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