Modulating native GABA A receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death

Pediatric brain cancer medulloblastoma (MB) standard-of-care results in numerous comorbidities. MB is comprised of distinct molecular subgroups. Group 3 molecular subgroup patients have the highest relapse rates and after standard-of-care have a 20% survival. Group 3 tumors have high expression of G...

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Veröffentlicht in:	Journal of neuro-oncology 2019-05, Vol.142 (3), p.411
Hauptverfasser:	Kallay, Laura, Keskin, Havva, Ross, Alexandra, Rupji, Manali, Moody, Olivia A, Wang, Xin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael Rajesh, Cottrill, Kirsten A, Nuckols, T Austin, Xu, Maxwell, Martinson, Deborah E, Tranghese, Frank, Pei, Yanxin, Cook, James M, Kowalski, Jeanne, Taylor, Michael D, Jenkins, Andrew, Pomeranz Krummel, Daniel A, Sengupta, Soma
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Benzodiazepines - pharmacology Cell Death - drug effects Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - metabolism Cerebellar Neoplasms - pathology Gene Expression Profiling Humans Medulloblastoma - drug therapy Medulloblastoma - metabolism Medulloblastoma - pathology Receptors, GABA-A - chemistry Receptors, GABA-A - metabolism Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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