Neurochemical impact of the 5-HT 2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain
Serotonin2C receptor (5-HT ) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT receptor agonist WAY-16...
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| Veröffentlicht in: | Neurochemistry international 2019-03, Vol.124, p.245 |
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| creator | Chagraoui, Abdeslam Whitestone, Sara Baassiri, Lynn Manem, Julien Di Giovanni, Giuseppe De Deurwaerdère, Philippe |
| description | Serotonin2C receptor (5-HT
) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT
receptor agonist WAY-163909 (0.3 and 3 mg/kg; i.p.) on the tissue concentration of dopamine (DA), 5-HT and noradrenaline (NA) in 29 rat brain regions related to motor, cognitive, mood and vegetative networks. We found that WAY-163909, without altering the tissue concentration of NA, increased 5-HT concentrations in the medial orbitofrontal cortex and the motor cortex M2 at 3 mg/kg and decreased it in the dorsolateral orbitofrontal cortex at 0.3 mg/kg. WAY-163909 enhanced DA concentrations in the central nucleus of the amygdala at 0.3 mg/kg and reduced it in the dorsal hypothalamus at 3 mg/kg. Using correlative analysis of the tissue content of monoamines, WAY-163909 dramatically changed the profile and the pattern of the correlations within and between monoaminergic systems without drastically changing the total number of these correlations. The profile of these changes in correlations was dose-dependent as it was very different between the two doses within and among monoaminergic systems. In conclusion, the data indicated that the 5-HT
receptor agonist WAY-163909 quantitatively alters monoamine content in very few regions but promotes multiple changes of monoaminergic connectivity in the brain. |
| doi_str_mv | 10.1016/j.neuint.2019.01.019 |
| format | Article |
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receptor agonist WAY-163909 (0.3 and 3 mg/kg; i.p.) on the tissue concentration of dopamine (DA), 5-HT and noradrenaline (NA) in 29 rat brain regions related to motor, cognitive, mood and vegetative networks. We found that WAY-163909, without altering the tissue concentration of NA, increased 5-HT concentrations in the medial orbitofrontal cortex and the motor cortex M2 at 3 mg/kg and decreased it in the dorsolateral orbitofrontal cortex at 0.3 mg/kg. WAY-163909 enhanced DA concentrations in the central nucleus of the amygdala at 0.3 mg/kg and reduced it in the dorsal hypothalamus at 3 mg/kg. Using correlative analysis of the tissue content of monoamines, WAY-163909 dramatically changed the profile and the pattern of the correlations within and between monoaminergic systems without drastically changing the total number of these correlations. The profile of these changes in correlations was dose-dependent as it was very different between the two doses within and among monoaminergic systems. In conclusion, the data indicated that the 5-HT
receptor agonist WAY-163909 quantitatively alters monoamine content in very few regions but promotes multiple changes of monoaminergic connectivity in the brain.</description><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2019.01.019</identifier><identifier>PMID: 30685320</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Azepines - pharmacology ; Biogenic Monoamines - agonists ; Biogenic Monoamines - antagonists & inhibitors ; Biogenic Monoamines - metabolism ; Brain - drug effects ; Brain - metabolism ; Indoles - pharmacology ; Male ; Rats ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT2C - metabolism ; Serotonin 5-HT2 Receptor Agonists - pharmacology</subject><ispartof>Neurochemistry international, 2019-03, Vol.124, p.245</ispartof><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30685320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chagraoui, Abdeslam</creatorcontrib><creatorcontrib>Whitestone, Sara</creatorcontrib><creatorcontrib>Baassiri, Lynn</creatorcontrib><creatorcontrib>Manem, Julien</creatorcontrib><creatorcontrib>Di Giovanni, Giuseppe</creatorcontrib><creatorcontrib>De Deurwaerdère, Philippe</creatorcontrib><title>Neurochemical impact of the 5-HT 2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>Serotonin2C receptor (5-HT
) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT
receptor agonist WAY-163909 (0.3 and 3 mg/kg; i.p.) on the tissue concentration of dopamine (DA), 5-HT and noradrenaline (NA) in 29 rat brain regions related to motor, cognitive, mood and vegetative networks. We found that WAY-163909, without altering the tissue concentration of NA, increased 5-HT concentrations in the medial orbitofrontal cortex and the motor cortex M2 at 3 mg/kg and decreased it in the dorsolateral orbitofrontal cortex at 0.3 mg/kg. WAY-163909 enhanced DA concentrations in the central nucleus of the amygdala at 0.3 mg/kg and reduced it in the dorsal hypothalamus at 3 mg/kg. Using correlative analysis of the tissue content of monoamines, WAY-163909 dramatically changed the profile and the pattern of the correlations within and between monoaminergic systems without drastically changing the total number of these correlations. The profile of these changes in correlations was dose-dependent as it was very different between the two doses within and among monoaminergic systems. In conclusion, the data indicated that the 5-HT
receptor agonist WAY-163909 quantitatively alters monoamine content in very few regions but promotes multiple changes of monoaminergic connectivity in the brain.</description><subject>Animals</subject><subject>Azepines - pharmacology</subject><subject>Biogenic Monoamines - agonists</subject><subject>Biogenic Monoamines - antagonists & inhibitors</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Indoles - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Serotonin, 5-HT2C - metabolism</subject><subject>Serotonin 5-HT2 Receptor Agonists - pharmacology</subject><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j8tKAzEUQIMgtlb_QOT-wIx5zSRZluILim4K4qokmTs2pZMMmczCv1d8wIGzO3AIuWG0ZpS1d8c64hxiqTllpqbsG3NGlkwrXhnVyAW5nKYjpVQZ2lyQhaCtbgSnS3J6wTknf8AheHuCMIzWF0g9lANCUz3tgG8go8expAz2I8UwFXhbv1esFYYaSBGGFJMdQkQoYZpmBJ9iwVggxJ9MtgVctiFekfPenia8_vOK7B7ud5unavv6-LxZb6vRiFJJ0StHZcew7620LdMGpaTecddp3UnBtBOq9VJz2Tk0smXSa2ONQqYEd2JFbn-z4-wG7PZjDoPNn_v_a_EF7bNYtw</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Chagraoui, Abdeslam</creator><creator>Whitestone, Sara</creator><creator>Baassiri, Lynn</creator><creator>Manem, Julien</creator><creator>Di Giovanni, Giuseppe</creator><creator>De Deurwaerdère, Philippe</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201903</creationdate><title>Neurochemical impact of the 5-HT 2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain</title><author>Chagraoui, Abdeslam ; Whitestone, Sara ; Baassiri, Lynn ; Manem, Julien ; Di Giovanni, Giuseppe ; De Deurwaerdère, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-43f7b04d1effa4a6189e440cb2bd88d4318b376c4824dbe94614c89a97e1732b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Azepines - pharmacology</topic><topic>Biogenic Monoamines - agonists</topic><topic>Biogenic Monoamines - antagonists & inhibitors</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Indoles - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Serotonin, 5-HT2C - metabolism</topic><topic>Serotonin 5-HT2 Receptor Agonists - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chagraoui, Abdeslam</creatorcontrib><creatorcontrib>Whitestone, Sara</creatorcontrib><creatorcontrib>Baassiri, Lynn</creatorcontrib><creatorcontrib>Manem, Julien</creatorcontrib><creatorcontrib>Di Giovanni, Giuseppe</creatorcontrib><creatorcontrib>De Deurwaerdère, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chagraoui, Abdeslam</au><au>Whitestone, Sara</au><au>Baassiri, Lynn</au><au>Manem, Julien</au><au>Di Giovanni, Giuseppe</au><au>De Deurwaerdère, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurochemical impact of the 5-HT 2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2019-03</date><risdate>2019</risdate><volume>124</volume><spage>245</spage><pages>245-</pages><eissn>1872-9754</eissn><abstract>Serotonin2C receptor (5-HT
) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT
receptor agonist WAY-163909 (0.3 and 3 mg/kg; i.p.) on the tissue concentration of dopamine (DA), 5-HT and noradrenaline (NA) in 29 rat brain regions related to motor, cognitive, mood and vegetative networks. We found that WAY-163909, without altering the tissue concentration of NA, increased 5-HT concentrations in the medial orbitofrontal cortex and the motor cortex M2 at 3 mg/kg and decreased it in the dorsolateral orbitofrontal cortex at 0.3 mg/kg. WAY-163909 enhanced DA concentrations in the central nucleus of the amygdala at 0.3 mg/kg and reduced it in the dorsal hypothalamus at 3 mg/kg. Using correlative analysis of the tissue content of monoamines, WAY-163909 dramatically changed the profile and the pattern of the correlations within and between monoaminergic systems without drastically changing the total number of these correlations. The profile of these changes in correlations was dose-dependent as it was very different between the two doses within and among monoaminergic systems. In conclusion, the data indicated that the 5-HT
receptor agonist WAY-163909 quantitatively alters monoamine content in very few regions but promotes multiple changes of monoaminergic connectivity in the brain.</abstract><cop>England</cop><pmid>30685320</pmid><doi>10.1016/j.neuint.2019.01.019</doi></addata></record> |
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| subjects | Animals Azepines - pharmacology Biogenic Monoamines - agonists Biogenic Monoamines - antagonists & inhibitors Biogenic Monoamines - metabolism Brain - drug effects Brain - metabolism Indoles - pharmacology Male Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2C - metabolism Serotonin 5-HT2 Receptor Agonists - pharmacology |
| title | Neurochemical impact of the 5-HT 2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain |
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