The m 6 A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

N -methyladenosine (m6A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its functions in bladder cancer (BCa) remain elusive. Here, we discovered that methyltransferase-like 3 (METTL3), a major RNA N -adenosine methylt...

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Veröffentlicht in:	Oncogene 2019-05, Vol.38 (19), p.3667
Hauptverfasser:	Cheng, Maosheng, Sheng, Lu, Gao, Qian, Xiong, Qiuchan, Zhang, Haojie, Wu, Mingqing, Liang, Yu, Zhu, Fengyu, Zhang, Yingyin, Zhang, Xiuhong, Yuan, Quan, Li, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - genetics Adenosine - metabolism Animals Cell Movement Cell Proliferation Gene Expression Regulation, Neoplastic Humans I-kappa B Kinase - genetics I-kappa B Kinase - metabolism Male Methyltransferases - genetics Methyltransferases - metabolism Mice, Inbred BALB C Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - metabolism Signal Transduction Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcriptional Elongation Factors - metabolism Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Xenograft Model Antitumor Assays
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