Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions
Recent advances in microfluidic technologies have enabled production of micro-scale compound bubbles that consist of gaseous cores surrounded by thin liquid shells, achieving control and uniformity not possible using conventional techniques. These compound bubbles have demonstrated enormous utility...
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| Veröffentlicht in: | Lab on a chip 2019-02, Vol.19 (4), p.665-673 |
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| creator | Jeong, Heon-Ho Chen, Zhuo Yadavali, Sagar Xu, Jianhong Issadore, David Lee, Daeyeon |
| description | Recent advances in microfluidic technologies have enabled production of micro-scale compound bubbles that consist of gaseous cores surrounded by thin liquid shells, achieving control and uniformity not possible using conventional techniques. These compound bubbles have demonstrated enormous utility as functional materials for drug delivery, as ultra-lightweight structural materials, as engineered acoustic materials, and also as separating agents for extraction of metal ions from waste fluid streams. Despite these successful demonstrations, compound bubbles have largely remained at the laboratory-scale due to the slow production rates endemic to microfluidics ( |
| doi_str_mv | 10.1039/c8lc01267a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_30657155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179382718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-f3ab1d87c3bc07c8f5aff70f671ba9bf8500cd4b3e576dd67f1321401e694123</originalsourceid><addsrcrecordid>eNpdkk1rFTEYhUOxtLW6ca8E3JTC1GQyk2Q2QrnUVrjQTfchn9eUzGRMJkX99aa9dbSuknAeDud9TwB4h9EFRmT4pHnQCLeUyQNwgjtGGoT58Gq9D-wYvM75HiHcd5QfgWOCaM9w35-AtJVpZ5usZbBwTtEUvfg4weigjuMcy2SgKkoFm2HJftrBWSYZgg3-lzVw9DpFF4o3XmfoYoLWOa-9nRZofyxJrm6jXWSA9ZHfgEMnQ7Zvn89TcPfl6m5z02xvr79uLreN7lq-NI5IhQ1nmiiNmOaul84x5CjDSg7K8R4hbTpFbM-oMZQ5TFrcIWzp0OGWnILPe9u5qNEaXSPV4GJOfpTpp4jSi5fK5L-JXXwQlLCWEFwNzp4NUvxebF7E6LO2IcjJxpJFi9lAeMswr-jH_9D7WNJUp3ukOCUDQaRS53uq7iznZN0aBiPx2KTY8O3mqcnLCn_4N_6K_qmuAu_3QMp6Vf9-BfIbncml7Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2178639303</pqid></control><display><type>article</type><title>Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Jeong, Heon-Ho ; Chen, Zhuo ; Yadavali, Sagar ; Xu, Jianhong ; Issadore, David ; Lee, Daeyeon</creator><creatorcontrib>Jeong, Heon-Ho ; Chen, Zhuo ; Yadavali, Sagar ; Xu, Jianhong ; Issadore, David ; Lee, Daeyeon</creatorcontrib><description>Recent advances in microfluidic technologies have enabled production of micro-scale compound bubbles that consist of gaseous cores surrounded by thin liquid shells, achieving control and uniformity not possible using conventional techniques. These compound bubbles have demonstrated enormous utility as functional materials for drug delivery, as ultra-lightweight structural materials, as engineered acoustic materials, and also as separating agents for extraction of metal ions from waste fluid streams. Despite these successful demonstrations, compound bubbles have largely remained at the laboratory-scale due to the slow production rates endemic to microfluidics (<10 mL h
−1
). Although parallelization approaches have enabled large-scale production of simple emulsions and bubbles, its application to the production of higher order dispersions such as compound bubbles has been limited because the optimal processing window for the production of uniform compound bubbles is relatively narrow and the required channel geometry is quite complex. In this report, we demonstrate the parallelization of multi-stage flow focusing droplet generators that produce compound ternary bubbles. We parallelize 400 multi-stage FFG devices, generating up to 3 L (∼10
11
bubbles) of monodispersed (CV < 5%) compound bubbles in less than 1 hour. We show that it is critical to use multi-height channels and operate each individual generator in a flow regime that is minimally sensitive to variations in the flow rate to reliably produce uniform compound bubbles. To demonstrate the utility of our parallelized device, we take advantage of the buoyancy and the high mass transfer rate that comes from the thin shells of gas-in-oil-in-water compound bubbles to rapidly extract Nd ions from a model waste stream.
Parallelization of multistage flow focusing generators enables large scale production of micro-scale compound bubbles that consist of gaseous cores and thin liquid shells with control and uniformity not possible using conventional techniques.</description><identifier>ISSN: 1473-0197</identifier><identifier>ISSN: 1473-0189</identifier><identifier>EISSN: 1473-0189</identifier><identifier>DOI: 10.1039/c8lc01267a</identifier><identifier>PMID: 30657155</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Bubbles ; Drug delivery systems ; Emulsions ; Flow velocity ; Gases - chemistry ; Ions - chemistry ; Ions - isolation & purification ; Mass transfer ; Metal ions ; Microfluidic Analytical Techniques - instrumentation ; Microfluidics ; Neodymium - chemistry ; Neodymium - isolation & purification ; Oils - chemistry ; Particle Size ; Surface Properties ; Thin walled shells ; Waste management ; Water - chemistry</subject><ispartof>Lab on a chip, 2019-02, Vol.19 (4), p.665-673</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-f3ab1d87c3bc07c8f5aff70f671ba9bf8500cd4b3e576dd67f1321401e694123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30657155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Heon-Ho</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Yadavali, Sagar</creatorcontrib><creatorcontrib>Xu, Jianhong</creatorcontrib><creatorcontrib>Issadore, David</creatorcontrib><creatorcontrib>Lee, Daeyeon</creatorcontrib><title>Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions</title><title>Lab on a chip</title><addtitle>Lab Chip</addtitle><description>Recent advances in microfluidic technologies have enabled production of micro-scale compound bubbles that consist of gaseous cores surrounded by thin liquid shells, achieving control and uniformity not possible using conventional techniques. These compound bubbles have demonstrated enormous utility as functional materials for drug delivery, as ultra-lightweight structural materials, as engineered acoustic materials, and also as separating agents for extraction of metal ions from waste fluid streams. Despite these successful demonstrations, compound bubbles have largely remained at the laboratory-scale due to the slow production rates endemic to microfluidics (<10 mL h
−1
). Although parallelization approaches have enabled large-scale production of simple emulsions and bubbles, its application to the production of higher order dispersions such as compound bubbles has been limited because the optimal processing window for the production of uniform compound bubbles is relatively narrow and the required channel geometry is quite complex. In this report, we demonstrate the parallelization of multi-stage flow focusing droplet generators that produce compound ternary bubbles. We parallelize 400 multi-stage FFG devices, generating up to 3 L (∼10
11
bubbles) of monodispersed (CV < 5%) compound bubbles in less than 1 hour. We show that it is critical to use multi-height channels and operate each individual generator in a flow regime that is minimally sensitive to variations in the flow rate to reliably produce uniform compound bubbles. To demonstrate the utility of our parallelized device, we take advantage of the buoyancy and the high mass transfer rate that comes from the thin shells of gas-in-oil-in-water compound bubbles to rapidly extract Nd ions from a model waste stream.
Parallelization of multistage flow focusing generators enables large scale production of micro-scale compound bubbles that consist of gaseous cores and thin liquid shells with control and uniformity not possible using conventional techniques.</description><subject>Bubbles</subject><subject>Drug delivery systems</subject><subject>Emulsions</subject><subject>Flow velocity</subject><subject>Gases - chemistry</subject><subject>Ions - chemistry</subject><subject>Ions - isolation & purification</subject><subject>Mass transfer</subject><subject>Metal ions</subject><subject>Microfluidic Analytical Techniques - instrumentation</subject><subject>Microfluidics</subject><subject>Neodymium - chemistry</subject><subject>Neodymium - isolation & purification</subject><subject>Oils - chemistry</subject><subject>Particle Size</subject><subject>Surface Properties</subject><subject>Thin walled shells</subject><subject>Waste management</subject><subject>Water - chemistry</subject><issn>1473-0197</issn><issn>1473-0189</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkk1rFTEYhUOxtLW6ca8E3JTC1GQyk2Q2QrnUVrjQTfchn9eUzGRMJkX99aa9dbSuknAeDud9TwB4h9EFRmT4pHnQCLeUyQNwgjtGGoT58Gq9D-wYvM75HiHcd5QfgWOCaM9w35-AtJVpZ5usZbBwTtEUvfg4weigjuMcy2SgKkoFm2HJftrBWSYZgg3-lzVw9DpFF4o3XmfoYoLWOa-9nRZofyxJrm6jXWSA9ZHfgEMnQ7Zvn89TcPfl6m5z02xvr79uLreN7lq-NI5IhQ1nmiiNmOaul84x5CjDSg7K8R4hbTpFbM-oMZQ5TFrcIWzp0OGWnILPe9u5qNEaXSPV4GJOfpTpp4jSi5fK5L-JXXwQlLCWEFwNzp4NUvxebF7E6LO2IcjJxpJFi9lAeMswr-jH_9D7WNJUp3ukOCUDQaRS53uq7iznZN0aBiPx2KTY8O3mqcnLCn_4N_6K_qmuAu_3QMp6Vf9-BfIbncml7Q</recordid><startdate>20190212</startdate><enddate>20190212</enddate><creator>Jeong, Heon-Ho</creator><creator>Chen, Zhuo</creator><creator>Yadavali, Sagar</creator><creator>Xu, Jianhong</creator><creator>Issadore, David</creator><creator>Lee, Daeyeon</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190212</creationdate><title>Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions</title><author>Jeong, Heon-Ho ; Chen, Zhuo ; Yadavali, Sagar ; Xu, Jianhong ; Issadore, David ; Lee, Daeyeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-f3ab1d87c3bc07c8f5aff70f671ba9bf8500cd4b3e576dd67f1321401e694123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bubbles</topic><topic>Drug delivery systems</topic><topic>Emulsions</topic><topic>Flow velocity</topic><topic>Gases - chemistry</topic><topic>Ions - chemistry</topic><topic>Ions - isolation & purification</topic><topic>Mass transfer</topic><topic>Metal ions</topic><topic>Microfluidic Analytical Techniques - instrumentation</topic><topic>Microfluidics</topic><topic>Neodymium - chemistry</topic><topic>Neodymium - isolation & purification</topic><topic>Oils - chemistry</topic><topic>Particle Size</topic><topic>Surface Properties</topic><topic>Thin walled shells</topic><topic>Waste management</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Heon-Ho</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Yadavali, Sagar</creatorcontrib><creatorcontrib>Xu, Jianhong</creatorcontrib><creatorcontrib>Issadore, David</creatorcontrib><creatorcontrib>Lee, Daeyeon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Heon-Ho</au><au>Chen, Zhuo</au><au>Yadavali, Sagar</au><au>Xu, Jianhong</au><au>Issadore, David</au><au>Lee, Daeyeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2019-02-12</date><risdate>2019</risdate><volume>19</volume><issue>4</issue><spage>665</spage><epage>673</epage><pages>665-673</pages><issn>1473-0197</issn><issn>1473-0189</issn><eissn>1473-0189</eissn><abstract>Recent advances in microfluidic technologies have enabled production of micro-scale compound bubbles that consist of gaseous cores surrounded by thin liquid shells, achieving control and uniformity not possible using conventional techniques. These compound bubbles have demonstrated enormous utility as functional materials for drug delivery, as ultra-lightweight structural materials, as engineered acoustic materials, and also as separating agents for extraction of metal ions from waste fluid streams. Despite these successful demonstrations, compound bubbles have largely remained at the laboratory-scale due to the slow production rates endemic to microfluidics (<10 mL h
−1
). Although parallelization approaches have enabled large-scale production of simple emulsions and bubbles, its application to the production of higher order dispersions such as compound bubbles has been limited because the optimal processing window for the production of uniform compound bubbles is relatively narrow and the required channel geometry is quite complex. In this report, we demonstrate the parallelization of multi-stage flow focusing droplet generators that produce compound ternary bubbles. We parallelize 400 multi-stage FFG devices, generating up to 3 L (∼10
11
bubbles) of monodispersed (CV < 5%) compound bubbles in less than 1 hour. We show that it is critical to use multi-height channels and operate each individual generator in a flow regime that is minimally sensitive to variations in the flow rate to reliably produce uniform compound bubbles. To demonstrate the utility of our parallelized device, we take advantage of the buoyancy and the high mass transfer rate that comes from the thin shells of gas-in-oil-in-water compound bubbles to rapidly extract Nd ions from a model waste stream.
Parallelization of multistage flow focusing generators enables large scale production of micro-scale compound bubbles that consist of gaseous cores and thin liquid shells with control and uniformity not possible using conventional techniques.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30657155</pmid><doi>10.1039/c8lc01267a</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Bubbles Drug delivery systems Emulsions Flow velocity Gases - chemistry Ions - chemistry Ions - isolation & purification Mass transfer Metal ions Microfluidic Analytical Techniques - instrumentation Microfluidics Neodymium - chemistry Neodymium - isolation & purification Oils - chemistry Particle Size Surface Properties Thin walled shells Waste management Water - chemistry |
| title | Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions |
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