Efficacy and safety of tofacitinib in Japanese patients with rheumatoid arthritis by background methotrexate dose: A post hoc analysis of clinical trial data

Objectives: Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). We investigated concomitant methotrexate (MTX) dose on tofacitinib efficacy/safety in Japanese RA patients. Methods: This post hoc analysis pooled data from a 3-month phase 2 study (NCT00603512) and a 24...

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Veröffentlicht in:	Modern rheumatology 2019-09, Vol.29 (5), p.756-766
Hauptverfasser:	Takeuchi, Tsutomu, Yamanaka, Hisashi, Yamaoka, Kunihiro, Arai, Shoko, Toyoizumi, Shigeyuki, DeMasi, Ryan, Fukuma, Yuri, Hirose, Tomohiro, Sugiyama, Naonobu, Zwillich, Samuel H., Tanaka, Yoshiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Drug Therapy, Combination Female Humans Janus kinase Japan Male methotrexate Methotrexate - administration & dosage Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Piperidines - administration & dosage Piperidines - adverse effects Piperidines - therapeutic use Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - therapeutic use Pyrroles - administration & dosage Pyrroles - adverse effects Pyrroles - therapeutic use rheumatoid arthritis tofacitinib
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