WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug

Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In v...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Analytica chimica acta 2019-01, Vol.1046, p.99
Hauptverfasser: Ansari, S, Ansari, M Shahnawaze, Satsangee, S P, Jain, R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page 99
container_title Analytica chimica acta
container_volume 1046
creator Ansari, S
Ansari, M Shahnawaze
Satsangee, S P
Jain, R
description Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In view of this, an exemplary voltammetric approach is proposed here for determination of RZ utilizing glassy carbon electrode (GCE) fabricated with WO decorated graphene nanocomposite. The structural and morphological characterizations of modifier were made by employing XRD, FESEM, EDAX, HRTEM, XPS, Raman and FT-IR spectroscopy which revealed successful formation of the nanocomposite. As a result of high electrical conductivity and large effective surface area of WO nanoparticles and graphene nanosheets, the developed sensor WO /Graphene/GCE displayed effectual and unrelenting electron interceding behavior exhibiting higher peak currents at lower potentials for RZ oxidation. Using square wave voltammetry, the drug showcased well-defined voltammetric response in Britton-Robinson buffer at pH 4.5 in concentration range from 0.2-1.4 μM and 1.4-14 μM with the low detection limit of 0.13 μM. The developed protocol was then implemented successfully to quantify RZ in commercially accessible pharmaceutical tablets with satisfactory recovery (99.8%-100.2%). The experimental results illustrated the applicability of the fabricated sensor for drug quality control and clinical analysis along with pharmacokinetic studies.
doi_str_mv 10.1016/j.aca.2018.09.028
format Article
fullrecord <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_30482307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30482307</sourcerecordid><originalsourceid>FETCH-LOGICAL-p93t-67b50ed8214cc472667e38b307235df66ed8ddc4e43767b1de533ac67121d9d63</originalsourceid><addsrcrecordid>eNo1j01LAzEQhoMgtlZ_gBfJH9g1yaTJ1lsRv6DQS8FjySaz7ZZuEpL04L83oJ6G4XnfhxlCHjhrOePq6dQaa1rBeNeyVctEd0XmvNPQSBByRm5zPjHGBGfyhsyAyU4A03Ny-dpSoA5tSKago4dk4hE9Um98sGGKIY8FaW9yhXhGW1KwR5xGa840o88hPdM1jSnkWCEdQqLliNVY6joGT8NAjS9jY_xh9LXk0uVwR64Hc854_zcXZPf2unv5aDbb98-X9aaJKyiN0v2SoesEl9ZKLZTSCF1f7xawdINSlTlnJUrQNcsdLgGMVZoL7lZOwYI8_mrjpZ_Q7WMaJ5O-9__vww-Au1zJ</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ansari, S ; Ansari, M Shahnawaze ; Satsangee, S P ; Jain, R</creator><creatorcontrib>Ansari, S ; Ansari, M Shahnawaze ; Satsangee, S P ; Jain, R</creatorcontrib><description>Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In view of this, an exemplary voltammetric approach is proposed here for determination of RZ utilizing glassy carbon electrode (GCE) fabricated with WO decorated graphene nanocomposite. The structural and morphological characterizations of modifier were made by employing XRD, FESEM, EDAX, HRTEM, XPS, Raman and FT-IR spectroscopy which revealed successful formation of the nanocomposite. As a result of high electrical conductivity and large effective surface area of WO nanoparticles and graphene nanosheets, the developed sensor WO /Graphene/GCE displayed effectual and unrelenting electron interceding behavior exhibiting higher peak currents at lower potentials for RZ oxidation. Using square wave voltammetry, the drug showcased well-defined voltammetric response in Britton-Robinson buffer at pH 4.5 in concentration range from 0.2-1.4 μM and 1.4-14 μM with the low detection limit of 0.13 μM. The developed protocol was then implemented successfully to quantify RZ in commercially accessible pharmaceutical tablets with satisfactory recovery (99.8%-100.2%). The experimental results illustrated the applicability of the fabricated sensor for drug quality control and clinical analysis along with pharmacokinetic studies.</description><identifier>EISSN: 1873-4324</identifier><identifier>DOI: 10.1016/j.aca.2018.09.028</identifier><identifier>PMID: 30482307</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Angiogenesis Inhibitors - analysis ; Electrochemical Techniques ; Graphite - chemistry ; Molecular Structure ; Nanocomposites - chemistry ; Oxides - chemistry ; Particle Size ; Surface Properties ; Tungsten - chemistry</subject><ispartof>Analytica chimica acta, 2019-01, Vol.1046, p.99</ispartof><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30482307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ansari, S</creatorcontrib><creatorcontrib>Ansari, M Shahnawaze</creatorcontrib><creatorcontrib>Satsangee, S P</creatorcontrib><creatorcontrib>Jain, R</creatorcontrib><title>WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug</title><title>Analytica chimica acta</title><addtitle>Anal Chim Acta</addtitle><description>Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In view of this, an exemplary voltammetric approach is proposed here for determination of RZ utilizing glassy carbon electrode (GCE) fabricated with WO decorated graphene nanocomposite. The structural and morphological characterizations of modifier were made by employing XRD, FESEM, EDAX, HRTEM, XPS, Raman and FT-IR spectroscopy which revealed successful formation of the nanocomposite. As a result of high electrical conductivity and large effective surface area of WO nanoparticles and graphene nanosheets, the developed sensor WO /Graphene/GCE displayed effectual and unrelenting electron interceding behavior exhibiting higher peak currents at lower potentials for RZ oxidation. Using square wave voltammetry, the drug showcased well-defined voltammetric response in Britton-Robinson buffer at pH 4.5 in concentration range from 0.2-1.4 μM and 1.4-14 μM with the low detection limit of 0.13 μM. The developed protocol was then implemented successfully to quantify RZ in commercially accessible pharmaceutical tablets with satisfactory recovery (99.8%-100.2%). The experimental results illustrated the applicability of the fabricated sensor for drug quality control and clinical analysis along with pharmacokinetic studies.</description><subject>Angiogenesis Inhibitors - analysis</subject><subject>Electrochemical Techniques</subject><subject>Graphite - chemistry</subject><subject>Molecular Structure</subject><subject>Nanocomposites - chemistry</subject><subject>Oxides - chemistry</subject><subject>Particle Size</subject><subject>Surface Properties</subject><subject>Tungsten - chemistry</subject><issn>1873-4324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LAzEQhoMgtlZ_gBfJH9g1yaTJ1lsRv6DQS8FjySaz7ZZuEpL04L83oJ6G4XnfhxlCHjhrOePq6dQaa1rBeNeyVctEd0XmvNPQSBByRm5zPjHGBGfyhsyAyU4A03Ny-dpSoA5tSKago4dk4hE9Um98sGGKIY8FaW9yhXhGW1KwR5xGa840o88hPdM1jSnkWCEdQqLliNVY6joGT8NAjS9jY_xh9LXk0uVwR64Hc854_zcXZPf2unv5aDbb98-X9aaJKyiN0v2SoesEl9ZKLZTSCF1f7xawdINSlTlnJUrQNcsdLgGMVZoL7lZOwYI8_mrjpZ_Q7WMaJ5O-9__vww-Au1zJ</recordid><startdate>20190110</startdate><enddate>20190110</enddate><creator>Ansari, S</creator><creator>Ansari, M Shahnawaze</creator><creator>Satsangee, S P</creator><creator>Jain, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20190110</creationdate><title>WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug</title><author>Ansari, S ; Ansari, M Shahnawaze ; Satsangee, S P ; Jain, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-67b50ed8214cc472667e38b307235df66ed8ddc4e43767b1de533ac67121d9d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiogenesis Inhibitors - analysis</topic><topic>Electrochemical Techniques</topic><topic>Graphite - chemistry</topic><topic>Molecular Structure</topic><topic>Nanocomposites - chemistry</topic><topic>Oxides - chemistry</topic><topic>Particle Size</topic><topic>Surface Properties</topic><topic>Tungsten - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ansari, S</creatorcontrib><creatorcontrib>Ansari, M Shahnawaze</creatorcontrib><creatorcontrib>Satsangee, S P</creatorcontrib><creatorcontrib>Jain, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Analytica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ansari, S</au><au>Ansari, M Shahnawaze</au><au>Satsangee, S P</au><au>Jain, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug</atitle><jtitle>Analytica chimica acta</jtitle><addtitle>Anal Chim Acta</addtitle><date>2019-01-10</date><risdate>2019</risdate><volume>1046</volume><spage>99</spage><pages>99-</pages><eissn>1873-4324</eissn><abstract>Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In view of this, an exemplary voltammetric approach is proposed here for determination of RZ utilizing glassy carbon electrode (GCE) fabricated with WO decorated graphene nanocomposite. The structural and morphological characterizations of modifier were made by employing XRD, FESEM, EDAX, HRTEM, XPS, Raman and FT-IR spectroscopy which revealed successful formation of the nanocomposite. As a result of high electrical conductivity and large effective surface area of WO nanoparticles and graphene nanosheets, the developed sensor WO /Graphene/GCE displayed effectual and unrelenting electron interceding behavior exhibiting higher peak currents at lower potentials for RZ oxidation. Using square wave voltammetry, the drug showcased well-defined voltammetric response in Britton-Robinson buffer at pH 4.5 in concentration range from 0.2-1.4 μM and 1.4-14 μM with the low detection limit of 0.13 μM. The developed protocol was then implemented successfully to quantify RZ in commercially accessible pharmaceutical tablets with satisfactory recovery (99.8%-100.2%). The experimental results illustrated the applicability of the fabricated sensor for drug quality control and clinical analysis along with pharmacokinetic studies.</abstract><cop>Netherlands</cop><pmid>30482307</pmid><doi>10.1016/j.aca.2018.09.028</doi></addata></record>
fulltext fulltext
identifier EISSN: 1873-4324
ispartof Analytica chimica acta, 2019-01, Vol.1046, p.99
issn 1873-4324
language eng
recordid cdi_pubmed_primary_30482307
source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Angiogenesis Inhibitors - analysis
Electrochemical Techniques
Graphite - chemistry
Molecular Structure
Nanocomposites - chemistry
Oxides - chemistry
Particle Size
Surface Properties
Tungsten - chemistry
title WO 3 decorated graphene nanocomposite based electrochemical sensor: A prospect for the detection of anti-anginal drug
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T01%3A30%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=WO%203%20decorated%20graphene%20nanocomposite%20based%20electrochemical%20sensor:%20A%20prospect%20for%20the%20detection%20of%20anti-anginal%20drug&rft.jtitle=Analytica%20chimica%20acta&rft.au=Ansari,%20S&rft.date=2019-01-10&rft.volume=1046&rft.spage=99&rft.pages=99-&rft.eissn=1873-4324&rft_id=info:doi/10.1016/j.aca.2018.09.028&rft_dat=%3Cpubmed%3E30482307%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/30482307&rfr_iscdi=true