IDH1 R132H is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment

Recurrent heterozygous mutation of isocitrate dehydrogenase 1 gene ( ), predominantly resulting in histidine substitution at arginine 132, was first identified in glioma. The biological significance of IDH1 , however, has been controversial, and its prevalent association with glioma remains enigmati...

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Veröffentlicht in:	Oncotarget 2018-10, Vol.9 (80), p.35100
Hauptverfasser:	Tiburcio, Patricia D B, Xiao, Bing, Chai, Yi, Asper, Sydney, Tripp, Sheryl R, Gillespie, David L, Jensen, Randy L, Huang, L Eric
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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