Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment
Pancreatic polypeptide is said to be a marker of vagal tone in duodenal ulcer. To determine whether pancreatic polypeptide levels are related to the course of duodenal ulcer, we studied acid and pancreatic polypeptide responses to insulin in 80 patients with duodenal ulcer disease: 40 with unoperate...
Gespeichert in:
| Veröffentlicht in: | Scandinavian journal of gastroenterology 1988, Vol.23 (5), p.595-601 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 601 |
|---|---|
| container_issue | 5 |
| container_start_page | 595 |
| container_title | Scandinavian journal of gastroenterology |
| container_volume | 23 |
| creator | Rigaud, D. Mignon, M. Accary, J. P. Vatier, J. Cantowitz, F. Bonfils, S. |
| description | Pancreatic polypeptide is said to be a marker of vagal tone in duodenal ulcer. To determine whether pancreatic polypeptide levels are related to the course of duodenal ulcer, we studied acid and pancreatic polypeptide responses to insulin in 80 patients with duodenal ulcer disease: 40 with unoperated duodenal ulcer and 40 with proximal vagotomy. Data were analysed in accordance with the presence of an ulcer (active disease) and, when present, in accordance with the ulcer healing on medical treatment (cimetidine, 1 g/day for 4 weeks). In both groups acid and pancreatic polypeptide responses to hypoglycaemia were slightly correlated (r = 0.38) (p < 0.05). The basal pancreatic polypeptide level was higher in patients with active disease than in those with inactive disease, who had a basal level similar to that of normal subjects of the same age range. Like the insulin-stimulated acid secretion, the pancreatic polypeptide response to insulin hypoglycaemia was higher in patients with active disease than in those with inactive disease (p |
| doi_str_mv | 10.3109/00365528809093918 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_3041557</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78327900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-15dd069a4e7471b73ff2a3fc1aa0c655fc488d76e9ea6b9680cc06a13316fb0f3</originalsourceid><addsrcrecordid>eNp9kVFr2zAUhcXY6LJsP2APAz3tzetVZFvWtpfSbmsg0FLaZ6PIV0RFtjxJbsmf2G-uTMKgjA4EAp1zP13OIeQjgy-cgTwF4HVVrZoGJEguWfOKLFgFq0IIaF6TxawX2cDekncx3gNAJUp5Qk44lKyqxIL8uVaDDqiS1fTau_2IY7Id0huMox8i0uTpeoiTswPN52LyHQ7K0TunMXylF9YYDDgkusEHdHH2nGntQ5exSB9t2h2s-TXZB5v2VA0dXaf47IfbeYM-Y96TN0a5iB-O95Lc_fxxe35ZbK5-rc_PNoUugaWCVV0HtVQlilKwreDGrBQ3mikFOididNk0nahRoqq3sm5Aa6gV45zVZguGL8nnA3cM_veEMbW9jRqdUwP6Kbai4Sshc3xLwg5GHXyMAU07BtursG8ZtHMH7T8d5JlPR_i07bH7O3EMPevfD7odjA-9evTBdW1Se-eDCTk4G2f0y_hvz8Z3qFzaaRWwvfdTyO3E_yz3BM0OqQg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78327900</pqid></control><display><type>article</type><title>Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment</title><source>Taylor & Francis</source><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><creator>Rigaud, D. ; Mignon, M. ; Accary, J. P. ; Vatier, J. ; Cantowitz, F. ; Bonfils, S.</creator><creatorcontrib>Rigaud, D. ; Mignon, M. ; Accary, J. P. ; Vatier, J. ; Cantowitz, F. ; Bonfils, S.</creatorcontrib><description>Pancreatic polypeptide is said to be a marker of vagal tone in duodenal ulcer. To determine whether pancreatic polypeptide levels are related to the course of duodenal ulcer, we studied acid and pancreatic polypeptide responses to insulin in 80 patients with duodenal ulcer disease: 40 with unoperated duodenal ulcer and 40 with proximal vagotomy. Data were analysed in accordance with the presence of an ulcer (active disease) and, when present, in accordance with the ulcer healing on medical treatment (cimetidine, 1 g/day for 4 weeks). In both groups acid and pancreatic polypeptide responses to hypoglycaemia were slightly correlated (r = 0.38) (p < 0.05). The basal pancreatic polypeptide level was higher in patients with active disease than in those with inactive disease, who had a basal level similar to that of normal subjects of the same age range. Like the insulin-stimulated acid secretion, the pancreatic polypeptide response to insulin hypoglycaemia was higher in patients with active disease than in those with inactive disease (p<0.05): 26.1 ±3.9 versus 20.1 ± 4 nmol/1/120 min, respectively, in unoperated patients and 34.8 ± 2.2 versus 24.3 ± 2.5 nmol/l/120 min, respectively, after proximal vagotomy. In active disease the pancreatic polypeptide response to insulin hypoglycaemia was higher in subjects whose ulcer did not heal further after cimetidine therapy than in those whose ulcer did. These data suggest that the pancreatic polypeptide response to insulin is an indicator of duodenal ulcer activity and is related to the treatment efficacy. These relationships are partly mediated by increased vagal tone.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365528809093918</identifier><identifier>PMID: 3041557</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Cimetidine - therapeutic use ; Duodenal ulcer ; Duodenal Ulcer - physiopathology ; Duodenal Ulcer - therapy ; duodenal ulcer treatment ; Female ; Gastric Acid - metabolism ; gastric acid secretion ; Humans ; Hyperglycemia ; Insulin - pharmacology ; Male ; Middle Aged ; pancreatic polypeptide ; Pancreatic Polypeptide - blood ; Pancreatic Polypeptide - metabolism ; proximal vagotomy ; Vagotomy, Proximal Gastric</subject><ispartof>Scandinavian journal of gastroenterology, 1988, Vol.23 (5), p.595-601</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-15dd069a4e7471b73ff2a3fc1aa0c655fc488d76e9ea6b9680cc06a13316fb0f3</citedby><cites>FETCH-LOGICAL-c401t-15dd069a4e7471b73ff2a3fc1aa0c655fc488d76e9ea6b9680cc06a13316fb0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365528809093918$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365528809093918$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3041557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rigaud, D.</creatorcontrib><creatorcontrib>Mignon, M.</creatorcontrib><creatorcontrib>Accary, J. P.</creatorcontrib><creatorcontrib>Vatier, J.</creatorcontrib><creatorcontrib>Cantowitz, F.</creatorcontrib><creatorcontrib>Bonfils, S.</creatorcontrib><title>Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Pancreatic polypeptide is said to be a marker of vagal tone in duodenal ulcer. To determine whether pancreatic polypeptide levels are related to the course of duodenal ulcer, we studied acid and pancreatic polypeptide responses to insulin in 80 patients with duodenal ulcer disease: 40 with unoperated duodenal ulcer and 40 with proximal vagotomy. Data were analysed in accordance with the presence of an ulcer (active disease) and, when present, in accordance with the ulcer healing on medical treatment (cimetidine, 1 g/day for 4 weeks). In both groups acid and pancreatic polypeptide responses to hypoglycaemia were slightly correlated (r = 0.38) (p < 0.05). The basal pancreatic polypeptide level was higher in patients with active disease than in those with inactive disease, who had a basal level similar to that of normal subjects of the same age range. Like the insulin-stimulated acid secretion, the pancreatic polypeptide response to insulin hypoglycaemia was higher in patients with active disease than in those with inactive disease (p<0.05): 26.1 ±3.9 versus 20.1 ± 4 nmol/1/120 min, respectively, in unoperated patients and 34.8 ± 2.2 versus 24.3 ± 2.5 nmol/l/120 min, respectively, after proximal vagotomy. In active disease the pancreatic polypeptide response to insulin hypoglycaemia was higher in subjects whose ulcer did not heal further after cimetidine therapy than in those whose ulcer did. These data suggest that the pancreatic polypeptide response to insulin is an indicator of duodenal ulcer activity and is related to the treatment efficacy. These relationships are partly mediated by increased vagal tone.</description><subject>Adult</subject><subject>Cimetidine - therapeutic use</subject><subject>Duodenal ulcer</subject><subject>Duodenal Ulcer - physiopathology</subject><subject>Duodenal Ulcer - therapy</subject><subject>duodenal ulcer treatment</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>gastric acid secretion</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pancreatic polypeptide</subject><subject>Pancreatic Polypeptide - blood</subject><subject>Pancreatic Polypeptide - metabolism</subject><subject>proximal vagotomy</subject><subject>Vagotomy, Proximal Gastric</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFr2zAUhcXY6LJsP2APAz3tzetVZFvWtpfSbmsg0FLaZ6PIV0RFtjxJbsmf2G-uTMKgjA4EAp1zP13OIeQjgy-cgTwF4HVVrZoGJEguWfOKLFgFq0IIaF6TxawX2cDekncx3gNAJUp5Qk44lKyqxIL8uVaDDqiS1fTau_2IY7Id0huMox8i0uTpeoiTswPN52LyHQ7K0TunMXylF9YYDDgkusEHdHH2nGntQ5exSB9t2h2s-TXZB5v2VA0dXaf47IfbeYM-Y96TN0a5iB-O95Lc_fxxe35ZbK5-rc_PNoUugaWCVV0HtVQlilKwreDGrBQ3mikFOididNk0nahRoqq3sm5Aa6gV45zVZguGL8nnA3cM_veEMbW9jRqdUwP6Kbai4Sshc3xLwg5GHXyMAU07BtursG8ZtHMH7T8d5JlPR_i07bH7O3EMPevfD7odjA-9evTBdW1Se-eDCTk4G2f0y_hvz8Z3qFzaaRWwvfdTyO3E_yz3BM0OqQg</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Rigaud, D.</creator><creator>Mignon, M.</creator><creator>Accary, J. P.</creator><creator>Vatier, J.</creator><creator>Cantowitz, F.</creator><creator>Bonfils, S.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment</title><author>Rigaud, D. ; Mignon, M. ; Accary, J. P. ; Vatier, J. ; Cantowitz, F. ; Bonfils, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-15dd069a4e7471b73ff2a3fc1aa0c655fc488d76e9ea6b9680cc06a13316fb0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Cimetidine - therapeutic use</topic><topic>Duodenal ulcer</topic><topic>Duodenal Ulcer - physiopathology</topic><topic>Duodenal Ulcer - therapy</topic><topic>duodenal ulcer treatment</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>gastric acid secretion</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pancreatic polypeptide</topic><topic>Pancreatic Polypeptide - blood</topic><topic>Pancreatic Polypeptide - metabolism</topic><topic>proximal vagotomy</topic><topic>Vagotomy, Proximal Gastric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rigaud, D.</creatorcontrib><creatorcontrib>Mignon, M.</creatorcontrib><creatorcontrib>Accary, J. P.</creatorcontrib><creatorcontrib>Vatier, J.</creatorcontrib><creatorcontrib>Cantowitz, F.</creatorcontrib><creatorcontrib>Bonfils, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rigaud, D.</au><au>Mignon, M.</au><au>Accary, J. P.</au><au>Vatier, J.</au><au>Cantowitz, F.</au><au>Bonfils, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1988</date><risdate>1988</risdate><volume>23</volume><issue>5</issue><spage>595</spage><epage>601</epage><pages>595-601</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><abstract>Pancreatic polypeptide is said to be a marker of vagal tone in duodenal ulcer. To determine whether pancreatic polypeptide levels are related to the course of duodenal ulcer, we studied acid and pancreatic polypeptide responses to insulin in 80 patients with duodenal ulcer disease: 40 with unoperated duodenal ulcer and 40 with proximal vagotomy. Data were analysed in accordance with the presence of an ulcer (active disease) and, when present, in accordance with the ulcer healing on medical treatment (cimetidine, 1 g/day for 4 weeks). In both groups acid and pancreatic polypeptide responses to hypoglycaemia were slightly correlated (r = 0.38) (p < 0.05). The basal pancreatic polypeptide level was higher in patients with active disease than in those with inactive disease, who had a basal level similar to that of normal subjects of the same age range. Like the insulin-stimulated acid secretion, the pancreatic polypeptide response to insulin hypoglycaemia was higher in patients with active disease than in those with inactive disease (p<0.05): 26.1 ±3.9 versus 20.1 ± 4 nmol/1/120 min, respectively, in unoperated patients and 34.8 ± 2.2 versus 24.3 ± 2.5 nmol/l/120 min, respectively, after proximal vagotomy. In active disease the pancreatic polypeptide response to insulin hypoglycaemia was higher in subjects whose ulcer did not heal further after cimetidine therapy than in those whose ulcer did. These data suggest that the pancreatic polypeptide response to insulin is an indicator of duodenal ulcer activity and is related to the treatment efficacy. These relationships are partly mediated by increased vagal tone.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3041557</pmid><doi>10.3109/00365528809093918</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 1988, Vol.23 (5), p.595-601 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pubmed_primary_3041557 |
| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Adult Cimetidine - therapeutic use Duodenal ulcer Duodenal Ulcer - physiopathology Duodenal Ulcer - therapy duodenal ulcer treatment Female Gastric Acid - metabolism gastric acid secretion Humans Hyperglycemia Insulin - pharmacology Male Middle Aged pancreatic polypeptide Pancreatic Polypeptide - blood Pancreatic Polypeptide - metabolism proximal vagotomy Vagotomy, Proximal Gastric |
| title | Pancreatic Polypeptide Response to Insulin in Duodenal Ulcer: Different Levels in Accordance with Ulcer Activity and Its Response to Treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T05%3A39%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pancreatic%20Polypeptide%20Response%20to%20Insulin%20in%20Duodenal%20Ulcer:%20Different%20Levels%20in%20Accordance%20with%20Ulcer%20Activity%20and%20Its%20Response%20to%20Treatment&rft.jtitle=Scandinavian%20journal%20of%20gastroenterology&rft.au=Rigaud,%20D.&rft.date=1988&rft.volume=23&rft.issue=5&rft.spage=595&rft.epage=601&rft.pages=595-601&rft.issn=0036-5521&rft.eissn=1502-7708&rft_id=info:doi/10.3109/00365528809093918&rft_dat=%3Cproquest_pubme%3E78327900%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78327900&rft_id=info:pmid/3041557&rfr_iscdi=true |