The challenges of oral drug delivery via nanocarriers

The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For...

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Veröffentlicht in:	Drug delivery 2018, Vol.25 (1), p.1694-1705
Hauptverfasser:	Reinholz, Jonas, Landfester, Katharina, Mailänder, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals barrier Bioavailability biodegradable nanomaterial Critical Review Dermatology Diabetes Drug Carriers drug delivery Drug Delivery Systems - methods Drug dosages exocytosis Exocytosis - drug effects Human body Humans Insulin Nanocarrier Nanomaterials Nanoparticles Nanostructures Peptides Pharmaceuticals Proteins Small intestine Stomach transcytosis transport
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