Up-Regulation Thioredoxin Inhibits Advanced Glycation End Products-Induced Neurodegeneration

Background/Aims: Diabetic retinopathy (DR) is one of the most serious complications of diabetes and is the leading cause of adult blindness in developed countries. Advanced glycation end products (AGEs) accumulation in diabetes is associated with its complications. Thioredoxin (Trx) is a small molec...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-11, Vol.50 (5), p.1673-1686
Hauptverfasser:	Ren, Xiang, Wang, Ni-na, Qi, Hui, Qiu, Yuan-yuan, Zhang, Cheng-hong, Brown, Emily, Kong, Hui, Kong, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Cell Line Diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - pathology Diabetic retinopathy Diabetic Retinopathy - etiology Diabetic Retinopathy - metabolism Disease Electroretinography Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - pharmacology Kinases Laboratory animals Male Metabolism Metabolites Mice Mice, Inbred BALB C Neurodegeneration Original Paper Oxidative stress Pathogenesis Photoreceptors Proteins Reactive Oxygen Species - metabolism Retina Retina - metabolism Retinal Ganglion Cells - physiology Retinal Pigment Epithelium - physiology RNA Interference RNA, Small Interfering - metabolism Thioredoxin Thioredoxins - antagonists & inhibitors Thioredoxins - genetics Thioredoxins - metabolism Up-Regulation
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