Photodynamic Action of Merocyanine 540 on Artificial and Natural Cell Membranes: Involvement of Singlet Molecular Oxygen

The photochemistry of merocyanine 540 (MC 540), a sensitizing dye that binds preferentially to leukemia and electrically excitable cells, has been investigated. MC 540-mediated photooxidation of histidine, arachidonate, and unsaturated phospholipid vesicles was assessed by spin label oximetry and sh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-05, Vol.84 (9), p.2999-3003
Hauptverfasser:	Kalyanaraman, B., Feix, J. B., Sieber, F., Thomas, J. P., Girotti, A. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture ANIMAL CELLS Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS CELL CONSTITUENTS CELL KILLING Cell Line Cell Membrane - drug effects Cell Membrane - metabolism CELL MEMBRANES Cell physiology CHEMICAL REACTIONS CHEMISTRY CHOLESTEROL Cholesterols CYANINE DYES Dimyristoylphosphatidylcholine DISEASES DOSE-RESPONSE RELATIONSHIPS DYES Effects of physical and chemical agents ELECTROMAGNETIC RADIATION ELECTRON SPIN RESONANCE Electron Spin Resonance Spectroscopy ELEMENTS Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism erythrocytes Fluorescent Dyes fluorescent probes Fundamental and applied biological sciences. Psychology HEAVY WATER HEMIC DISEASES Humans HYDROGEN COMPOUNDS HYDROXY COMPOUNDS Irradiation LEUKEMIA Leukemia, Myeloid Lipid peroxides LIPIDS Liposomes MAGNETIC RESONANCE MEMBRANES merocyanine 540 Molecular and cellular biology NEAR ULTRAVIOLET RADIATION NEOPLASMS NONMETALS ORGANIC COMPOUNDS OXIDATION OXYGEN OXYGEN COMPOUNDS Oxygen consumption Phosphatidylcholines PHOTOCHEMISTRY Photooxidation Pyrimidinones - pharmacology RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOLOGY AND NUCLEAR MEDICINE RESONANCE Singlet Oxygen STEROIDS STEROLS TUMOR CELLS ULTRAVIOLET RADIATION vesicles WATER
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!