Outcomes across the tuberculosis care continuum among adolescents in Haiti
GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti. To evaluate tuberculosis (TB) care continuum outcomes among adolescents. Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the fol...
Gespeichert in:
| Veröffentlicht in: | Public health action 2018-09, Vol.8 (3), p.103-109 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109 |
|---|---|
| container_issue | 3 |
| container_start_page | 103 |
| container_title | Public health action |
| container_volume | 8 |
| creator | Reif, L. K. Rivera, V. Bertrand, R. Rouzier, V. Kutscher, E. Walsh, K. Charles, B. Pape, J. W. Fitzgerald, D. W. Koenig, S. P. McNairy, M. L. |
| description | GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti.
To evaluate tuberculosis (TB) care continuum outcomes among adolescents.
Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the following steps of the TB care continuum stratified by human immunodeficiency virus (HIV) status: diagnosis of microbiologically confirmed TB, initiation of anti-tuberculosis treatment, retention in care at 2 months on anti-tuberculosis treatment, and TB treatment success. Factors associated with attrition at each step were identified using multivariable regression.
A total of 1005 adolescents were diagnosed with active TB; 74 (7%) were HIV-positive at the time of TB diagnosis. HIV-positive patients had poorer outcomes than non-HIV-infected patients: 73% vs. 85% initiated anti-tuberculosis treatment (
< 0.01), 46% vs. 74% were retained in care at 2 months (
< 0.01), and 41% vs. 68% achieved TB treatment success (
< 0.01). Among those who initiated treatment, same-day initiation resulted in less treatment failure. Attrition before treatment initiation was associated with female sex and HIV coinfection. Attrition after treatment initiation was associated with age ⩾16 years and HIV coinfection.
Outcomes across the TB care continuum are suboptimal among adolescents, with only two thirds of patients achieving treatment success. Interventions tailored to adolescents are needed to improve retention in care, particularly for those who are co-infected with HIV. |
| doi_str_mv | 10.5588/pha.18.0021 |
| format | Article |
| fullrecord | <record><control><sourceid>pubtec_pubme</sourceid><recordid>TN_cdi_pubmed_primary_30271725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/pha/2018/00000008/00000003/art00003</ingid><sourcerecordid>iuatld/pha/2018/00000008/00000003/art00003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-a1ad2a92c10ce61d204f51d4701e5365435600e5c0c50af993d7af06da670faf3</originalsourceid><addsrcrecordid>eNpVkc1PGzEQxS1UBAg4cUc-VkJJx3bs3VwqFcRHKyQucLYGrzcx2rVTf1Tqf4-zoRGdi5_kn97MvCHkgsFcyrb9tlnjnLVzAM4OyAnnHGataPiXT_qYnKf0BrVUpVp-RI4F8IY1XJ6QX08lmzDaRNHEkBLNa0tzebXRlCEkl6jBaKkJPjtfykhxDH5FsQuDTcb6nKjz9AFddmfksMch2fOP95S83N0-3zzMHp_uf978eJwZ0UCeIcOO45IbBsYq1nFY9JJ1iwaYlULJhZAKwEoDRgL2y6XoGuxBdaga6LEXp-T7zndTXkfbbYeIOOhNdCPGvzqg0___eLfWq_BHK1abKFUNvn4YxPC72JT16Oouw4DehpI0Z0xy1bQMKnq1Q6dwou33bRjo7QF0PYBmrd4eoNKXnyfbs__irsD1DnB-VYdD_RZK9DUs7QrmoZvcOEx-U-2F0BjzJMQ7oZGXHg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2115267810</pqid></control><display><type>article</type><title>Outcomes across the tuberculosis care continuum among adolescents in Haiti</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Reif, L. K. ; Rivera, V. ; Bertrand, R. ; Rouzier, V. ; Kutscher, E. ; Walsh, K. ; Charles, B. ; Pape, J. W. ; Fitzgerald, D. W. ; Koenig, S. P. ; McNairy, M. L.</creator><creatorcontrib>Reif, L. K. ; Rivera, V. ; Bertrand, R. ; Rouzier, V. ; Kutscher, E. ; Walsh, K. ; Charles, B. ; Pape, J. W. ; Fitzgerald, D. W. ; Koenig, S. P. ; McNairy, M. L.</creatorcontrib><description>GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti.
To evaluate tuberculosis (TB) care continuum outcomes among adolescents.
Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the following steps of the TB care continuum stratified by human immunodeficiency virus (HIV) status: diagnosis of microbiologically confirmed TB, initiation of anti-tuberculosis treatment, retention in care at 2 months on anti-tuberculosis treatment, and TB treatment success. Factors associated with attrition at each step were identified using multivariable regression.
A total of 1005 adolescents were diagnosed with active TB; 74 (7%) were HIV-positive at the time of TB diagnosis. HIV-positive patients had poorer outcomes than non-HIV-infected patients: 73% vs. 85% initiated anti-tuberculosis treatment (
< 0.01), 46% vs. 74% were retained in care at 2 months (
< 0.01), and 41% vs. 68% achieved TB treatment success (
< 0.01). Among those who initiated treatment, same-day initiation resulted in less treatment failure. Attrition before treatment initiation was associated with female sex and HIV coinfection. Attrition after treatment initiation was associated with age ⩾16 years and HIV coinfection.
Outcomes across the TB care continuum are suboptimal among adolescents, with only two thirds of patients achieving treatment success. Interventions tailored to adolescents are needed to improve retention in care, particularly for those who are co-infected with HIV.</description><identifier>ISSN: 2220-8372</identifier><identifier>EISSN: 2220-8372</identifier><identifier>DOI: 10.5588/pha.18.0021</identifier><identifier>PMID: 30271725</identifier><language>eng</language><publisher>France: International Union Against Tuberculosis and Lung Disease</publisher><subject>Cascade Of Care ; HIV ; Original ; Youth</subject><ispartof>Public health action, 2018-09, Vol.8 (3), p.103-109</ispartof><rights>2018 The Union 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-a1ad2a92c10ce61d204f51d4701e5365435600e5c0c50af993d7af06da670faf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147066/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147066/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30271725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reif, L. K.</creatorcontrib><creatorcontrib>Rivera, V.</creatorcontrib><creatorcontrib>Bertrand, R.</creatorcontrib><creatorcontrib>Rouzier, V.</creatorcontrib><creatorcontrib>Kutscher, E.</creatorcontrib><creatorcontrib>Walsh, K.</creatorcontrib><creatorcontrib>Charles, B.</creatorcontrib><creatorcontrib>Pape, J. W.</creatorcontrib><creatorcontrib>Fitzgerald, D. W.</creatorcontrib><creatorcontrib>Koenig, S. P.</creatorcontrib><creatorcontrib>McNairy, M. L.</creatorcontrib><title>Outcomes across the tuberculosis care continuum among adolescents in Haiti</title><title>Public health action</title><addtitle>Public Health Action</addtitle><description>GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti.
To evaluate tuberculosis (TB) care continuum outcomes among adolescents.
Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the following steps of the TB care continuum stratified by human immunodeficiency virus (HIV) status: diagnosis of microbiologically confirmed TB, initiation of anti-tuberculosis treatment, retention in care at 2 months on anti-tuberculosis treatment, and TB treatment success. Factors associated with attrition at each step were identified using multivariable regression.
A total of 1005 adolescents were diagnosed with active TB; 74 (7%) were HIV-positive at the time of TB diagnosis. HIV-positive patients had poorer outcomes than non-HIV-infected patients: 73% vs. 85% initiated anti-tuberculosis treatment (
< 0.01), 46% vs. 74% were retained in care at 2 months (
< 0.01), and 41% vs. 68% achieved TB treatment success (
< 0.01). Among those who initiated treatment, same-day initiation resulted in less treatment failure. Attrition before treatment initiation was associated with female sex and HIV coinfection. Attrition after treatment initiation was associated with age ⩾16 years and HIV coinfection.
Outcomes across the TB care continuum are suboptimal among adolescents, with only two thirds of patients achieving treatment success. Interventions tailored to adolescents are needed to improve retention in care, particularly for those who are co-infected with HIV.</description><subject>Cascade Of Care</subject><subject>HIV</subject><subject>Original</subject><subject>Youth</subject><issn>2220-8372</issn><issn>2220-8372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkc1PGzEQxS1UBAg4cUc-VkJJx3bs3VwqFcRHKyQucLYGrzcx2rVTf1Tqf4-zoRGdi5_kn97MvCHkgsFcyrb9tlnjnLVzAM4OyAnnHGataPiXT_qYnKf0BrVUpVp-RI4F8IY1XJ6QX08lmzDaRNHEkBLNa0tzebXRlCEkl6jBaKkJPjtfykhxDH5FsQuDTcb6nKjz9AFddmfksMch2fOP95S83N0-3zzMHp_uf978eJwZ0UCeIcOO45IbBsYq1nFY9JJ1iwaYlULJhZAKwEoDRgL2y6XoGuxBdaga6LEXp-T7zndTXkfbbYeIOOhNdCPGvzqg0___eLfWq_BHK1abKFUNvn4YxPC72JT16Oouw4DehpI0Z0xy1bQMKnq1Q6dwou33bRjo7QF0PYBmrd4eoNKXnyfbs__irsD1DnB-VYdD_RZK9DUs7QrmoZvcOEx-U-2F0BjzJMQ7oZGXHg</recordid><startdate>20180921</startdate><enddate>20180921</enddate><creator>Reif, L. K.</creator><creator>Rivera, V.</creator><creator>Bertrand, R.</creator><creator>Rouzier, V.</creator><creator>Kutscher, E.</creator><creator>Walsh, K.</creator><creator>Charles, B.</creator><creator>Pape, J. W.</creator><creator>Fitzgerald, D. W.</creator><creator>Koenig, S. P.</creator><creator>McNairy, M. L.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>The Union</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180921</creationdate><title>Outcomes across the tuberculosis care continuum among adolescents in Haiti</title><author>Reif, L. K. ; Rivera, V. ; Bertrand, R. ; Rouzier, V. ; Kutscher, E. ; Walsh, K. ; Charles, B. ; Pape, J. W. ; Fitzgerald, D. W. ; Koenig, S. P. ; McNairy, M. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-a1ad2a92c10ce61d204f51d4701e5365435600e5c0c50af993d7af06da670faf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cascade Of Care</topic><topic>HIV</topic><topic>Original</topic><topic>Youth</topic><toplevel>online_resources</toplevel><creatorcontrib>Reif, L. K.</creatorcontrib><creatorcontrib>Rivera, V.</creatorcontrib><creatorcontrib>Bertrand, R.</creatorcontrib><creatorcontrib>Rouzier, V.</creatorcontrib><creatorcontrib>Kutscher, E.</creatorcontrib><creatorcontrib>Walsh, K.</creatorcontrib><creatorcontrib>Charles, B.</creatorcontrib><creatorcontrib>Pape, J. W.</creatorcontrib><creatorcontrib>Fitzgerald, D. W.</creatorcontrib><creatorcontrib>Koenig, S. P.</creatorcontrib><creatorcontrib>McNairy, M. L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Public health action</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reif, L. K.</au><au>Rivera, V.</au><au>Bertrand, R.</au><au>Rouzier, V.</au><au>Kutscher, E.</au><au>Walsh, K.</au><au>Charles, B.</au><au>Pape, J. W.</au><au>Fitzgerald, D. W.</au><au>Koenig, S. P.</au><au>McNairy, M. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes across the tuberculosis care continuum among adolescents in Haiti</atitle><jtitle>Public health action</jtitle><addtitle>Public Health Action</addtitle><date>2018-09-21</date><risdate>2018</risdate><volume>8</volume><issue>3</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>2220-8372</issn><eissn>2220-8372</eissn><abstract>GHESKIO (Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes) clinic, Port-au-Prince, Haiti.
To evaluate tuberculosis (TB) care continuum outcomes among adolescents.
Among a retrospective cohort of 10-24 year olds diagnosed with active TB, we report completion of the following steps of the TB care continuum stratified by human immunodeficiency virus (HIV) status: diagnosis of microbiologically confirmed TB, initiation of anti-tuberculosis treatment, retention in care at 2 months on anti-tuberculosis treatment, and TB treatment success. Factors associated with attrition at each step were identified using multivariable regression.
A total of 1005 adolescents were diagnosed with active TB; 74 (7%) were HIV-positive at the time of TB diagnosis. HIV-positive patients had poorer outcomes than non-HIV-infected patients: 73% vs. 85% initiated anti-tuberculosis treatment (
< 0.01), 46% vs. 74% were retained in care at 2 months (
< 0.01), and 41% vs. 68% achieved TB treatment success (
< 0.01). Among those who initiated treatment, same-day initiation resulted in less treatment failure. Attrition before treatment initiation was associated with female sex and HIV coinfection. Attrition after treatment initiation was associated with age ⩾16 years and HIV coinfection.
Outcomes across the TB care continuum are suboptimal among adolescents, with only two thirds of patients achieving treatment success. Interventions tailored to adolescents are needed to improve retention in care, particularly for those who are co-infected with HIV.</abstract><cop>France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>30271725</pmid><doi>10.5588/pha.18.0021</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2220-8372 |
| ispartof | Public health action, 2018-09, Vol.8 (3), p.103-109 |
| issn | 2220-8372 2220-8372 |
| language | eng |
| recordid | cdi_pubmed_primary_30271725 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Cascade Of Care HIV Original Youth |
| title | Outcomes across the tuberculosis care continuum among adolescents in Haiti |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A21%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubtec_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcomes%20across%20the%20tuberculosis%20care%20continuum%20among%20adolescents%20in%20Haiti&rft.jtitle=Public%20health%20action&rft.au=Reif,%20L.%20K.&rft.date=2018-09-21&rft.volume=8&rft.issue=3&rft.spage=103&rft.epage=109&rft.pages=103-109&rft.issn=2220-8372&rft.eissn=2220-8372&rft_id=info:doi/10.5588/pha.18.0021&rft_dat=%3Cpubtec_pubme%3Eiuatld/pha/2018/00000008/00000003/art00003%3C/pubtec_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2115267810&rft_id=info:pmid/30271725&rft_ingid=iuatld/pha/2018/00000008/00000003/art00003&rfr_iscdi=true |