miR-184 Inhibits Tumor Invasion, Migration and Metastasis in Nasopharyngeal Carcinoma by Targeting Notch2

Background/Aims: A recent study found that dysregulated microRNA-184 (miR-184) is involved in the proliferation and survival of nasopharyngeal carcinoma (NPC). This study aimed to evaluate the detailed mechanisms of invasion, migration and metastasis of NPC cells. Methods: Quantitative reverse-trans...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2018-10, Vol.49 (4), p.1564-1576
Hauptverfasser:	Zhu, Hong-Ming, Jiang, Xue-Song, Li, Hui-Zi, Qian, Lu-Xi, Du, Ming-Yu, Lu, Zhi-Wei, Wu, Jing, Tian, Xiao-Kang, Fei, Qian, He, Xia, Yin, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Antagomirs - metabolism Apoptosis Cadherins - metabolism Carcinoma - metabolism Carcinoma - pathology Care and treatment Cell adhesion & migration Cell cycle Cell growth Cell Line, Tumor Cell Movement EMT Epithelial-Mesenchymal Transition Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Invasion Liver cancer Male Medical prognosis Membrane proteins Metastasis Mice Mice, Inbred BALB C Mice, Nude MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-184 Nasopharyngeal cancer Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplasm Invasiveness Notch2 Original Paper Physiological aspects Proteins Receptor, Notch2 - antagonists & inhibitors Receptor, Notch2 - genetics Receptor, Notch2 - metabolism RNA Interference RNA, Small Interfering - metabolism Throat cancer Vimentin - metabolism
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