Structure-Function Analysis of Murine Interleukin 1: Biologically Active Polypeptides are at Least 127 Amino Acids Long and are Derived from the Carboxyl Terminus of a 270-Amino Acid Precursor

Murine interleukin 1 (IL-1) is initially synthesized as a 270-amino acid precursor protein. Guided by amino-terminal end sequence analyses of mouse macrophagederived IL-1, it was shown that expression of the carboxyl-terminal 156 amino acids (i.e., amino acids 115-270) of this precursor in Escherich...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-11, Vol.83 (21), p.8303-8307
Hauptverfasser:	DeChiara, Thomas M., Young, Daru, Semionow, Raina, Stern, Alvin S., Batula-Bernardo, Cheryl, Fiedler-Nagy, Christa, Kaffka, Kimberlee L., Kilian, Patricia L., Yamazaki, Shigeko, Mizel, Steven B., Lomedico, Peter T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - analysis Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Dinoprostone Escherichia coli - metabolism Fibroblasts Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-1 - analysis Interleukin-1 - biosynthesis Lymphocyte Activation Lymphokines, interleukins ( function, expression) Mice Microbial Collagenase - biosynthesis Molecules Plasmids Prostaglandins E - biosynthesis Protein precursors Protein Precursors - analysis Proteins Receptors Receptors, Immunologic - analysis Receptors, Interleukin-1 Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors Structure-Activity Relationship Synovial Membrane - metabolism T lymphocytes Thymocytes
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