AMPA-induced extracellular Zn 2+ influx into nigral dopaminergic neurons causes movement disorder in rats

On the basis of the findings that the rapid influx of extracellular Zn into nigral dopaminergic neurons causes dopaminergic neurodegeneration, here we report that AMPA causes movement disorder in rats. AMPA markedly increased turning behavior in response to apomorphine 1 and 2 weeks after AMPA injec...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2018-12, Vol.69, p.23
Hauptverfasser:	Tamano, Haruna, Morioka, Hiroki, Nishio, Ryusuke, Takeuchi, Azusa, Takeda, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - administration & dosage alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity Animals Chelating Agents - administration & dosage Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dyskinesia, Drug-Induced - metabolism Dyskinesia, Drug-Induced - prevention & control Extracellular Fluid - drug effects Extracellular Fluid - metabolism Injections, Intraventricular Male Rats Rats, Wistar Substantia Nigra - drug effects Substantia Nigra - metabolism Zinc - metabolism
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