Arrhythmias precede cardiomyopathy and remodeling of Ca 2+ handling proteins in a novel model of long QT syndrome

Deletion of QKP1507-1509 amino-acids in SCN5A gene product, the voltage-gated Na channel Nav1.5, has been associated with a large phenotypic spectrum of type 3 long QT syndrome, conduction disorder, dilated cardiomyopathy and high incidence of sudden death. The aim of this study was to develop and c...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2018-08, Vol.123, p.13
Hauptverfasser:	Montnach, Jérôme, Chizelle, Franck F, Belbachir, Nadjet, Castro, Claire, Li, Linwei, Loussouarn, Gildas, Toumaniantz, Gilles, Carcouët, Agnès, Meinzinger, Anne Julia, Shmerling, Doron, Benitah, Jean-Pierre, Gómez, Ana Maria, Charpentier, Flavien, Baró, Isabelle
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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