Activation of the mGlu 1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M 4 muscarinic receptor allosteric modulators

Recent clinical and preclinical studies suggest that selective activators of the M muscarinic acetylcholine receptor have potential as a novel treatment for schizophrenia. M activation inhibits striatal dopamine release by mobilizing endocannabinoids, providing a mechanism for local effects on dopam...

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Veröffentlicht in:	Molecular psychiatry 2020-11, Vol.25 (11), p.2786
Hauptverfasser:	Yohn, Samantha E, Foster, Daniel J, Covey, Dan P, Moehle, Mark S, Galbraith, Jordan, Garcia-Barrantes, Pedro M, Cho, Hyekyung P, Bubser, Michael, Blobaum, Anna L, Joffe, Max E, Cheer, Joseph F, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Animals Antipsychotic Agents - metabolism Glutamic Acid - metabolism Mice Mice, Inbred C57BL Receptor, Muscarinic M4 - metabolism Receptors, Metabotropic Glutamate - metabolism
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