Modification of α-lactose monohydrate as a direct compression excipient using roller compaction
Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted α-lactose monohydrate was...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2018-12, Vol.44 (12), p.2038-2047 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Abu Fara, Deeb Rashid, Iyad Alkhamis, Khouloud Al-Omari, Mahmoud Chowdhry, B. Z. Badwan, Adnan |
| description | Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted α-lactose monohydrate was investigated. Results were compared with data obtained using industrial spray-dried lactose and lactose samples with different degrees of crystallinity. XRPD analysis revealed that roller compaction reduced the crystallinity of α-lactose monohydrate, and the resulting material is similar to spray-dried lactose in behavior as a direct compression excipient. Roller compaction introduced desirable characteristics to the raw α-lactose monohydrate by inducing changes in crystallinity and particle morphology. Scanning electron microscopy results indicated that the compaction process converted some of the original torpedo-shaped crystals of α-lactose monohydrate into a more cylindrical shape with rounded edges. Compaction pressure and repetition of compaction have a significant effect on the modification of the crystallinity of the processed, raw α-lactose monohydrate. |
| doi_str_mv | 10.1080/03639045.2018.1508224 |
| format | Article |
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Scanning electron microscopy results indicated that the compaction process converted some of the original torpedo-shaped crystals of α-lactose monohydrate into a more cylindrical shape with rounded edges. Compaction pressure and repetition of compaction have a significant effect on the modification of the crystallinity of the processed, raw α-lactose monohydrate.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639045.2018.1508224</identifier><identifier>PMID: 30095020</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Chemistry, Pharmaceutical ; Co-processing ; crystallinity ; Drug Compounding - methods ; dry granulation ; Excipients - chemistry ; lactose ; Lactose - chemistry ; Particle Size ; Powders ; Pressure ; roller compaction ; spray dried lactose ; Tablets ; xrpd</subject><ispartof>Drug development and industrial pharmacy, 2018-12, Vol.44 (12), p.2038-2047</ispartof><rights>2018 Informa UK Limited, trading as Taylor & Francis Group 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-97aa02c003194a4a3f2de70b8526e5d973445532847c1a8d9121d956be7ca7c33</citedby><cites>FETCH-LOGICAL-c366t-97aa02c003194a4a3f2de70b8526e5d973445532847c1a8d9121d956be7ca7c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30095020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abu Fara, Deeb</creatorcontrib><creatorcontrib>Rashid, Iyad</creatorcontrib><creatorcontrib>Alkhamis, Khouloud</creatorcontrib><creatorcontrib>Al-Omari, Mahmoud</creatorcontrib><creatorcontrib>Chowdhry, B. Z.</creatorcontrib><creatorcontrib>Badwan, Adnan</creatorcontrib><title>Modification of α-lactose monohydrate as a direct compression excipient using roller compaction</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted α-lactose monohydrate was investigated. Results were compared with data obtained using industrial spray-dried lactose and lactose samples with different degrees of crystallinity. XRPD analysis revealed that roller compaction reduced the crystallinity of α-lactose monohydrate, and the resulting material is similar to spray-dried lactose in behavior as a direct compression excipient. Roller compaction introduced desirable characteristics to the raw α-lactose monohydrate by inducing changes in crystallinity and particle morphology. Scanning electron microscopy results indicated that the compaction process converted some of the original torpedo-shaped crystals of α-lactose monohydrate into a more cylindrical shape with rounded edges. Compaction pressure and repetition of compaction have a significant effect on the modification of the crystallinity of the processed, raw α-lactose monohydrate.</description><subject>Chemistry, Pharmaceutical</subject><subject>Co-processing</subject><subject>crystallinity</subject><subject>Drug Compounding - methods</subject><subject>dry granulation</subject><subject>Excipients - chemistry</subject><subject>lactose</subject><subject>Lactose - chemistry</subject><subject>Particle Size</subject><subject>Powders</subject><subject>Pressure</subject><subject>roller compaction</subject><subject>spray dried lactose</subject><subject>Tablets</subject><subject>xrpd</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtOwzAURS0EgvJZAshDJinPdpzEMxDiJ4GYwNi82g4YJXGxU0GXxUZYEwktDBndybn3SoeQQwZTBhWcgCiEglxOObBqyiRUnOcbZMIkh0yWBd8kk5HJRmiH7Kb0CsC4knKb7AgAJYHDhDzdBetrb7D3oaOhpl-fWYOmD8nRNnThZWkj9o5iokitj8701IR2Hl1KY8N9GD_3ruvpIvnumcbQNC7-IMPKQOyTrRqb5A7WuUceLy8ezq-z2_urm_Oz28yIougzVSICNwCCqRxzFDW3roRZJXnhpFWlyHMpBa_y0jCsrGKcWSWLmSsNlkaIPXK82p3H8LZwqdetT8Y1DXYuLJLmUJVSCcmrAZUr1MSQUnS1nkffYlxqBnqUq3_l6lGuXssdekfri8Wsdfav9WtzAE5XgO_qEFt8D7GxusdlE2IdsTM-afH_xzf5K4nX</recordid><startdate>20181202</startdate><enddate>20181202</enddate><creator>Abu Fara, Deeb</creator><creator>Rashid, Iyad</creator><creator>Alkhamis, Khouloud</creator><creator>Al-Omari, Mahmoud</creator><creator>Chowdhry, B. 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Z.</au><au>Badwan, Adnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of α-lactose monohydrate as a direct compression excipient using roller compaction</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2018-12-02</date><risdate>2018</risdate><volume>44</volume><issue>12</issue><spage>2038</spage><epage>2047</epage><pages>2038-2047</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted α-lactose monohydrate was investigated. Results were compared with data obtained using industrial spray-dried lactose and lactose samples with different degrees of crystallinity. XRPD analysis revealed that roller compaction reduced the crystallinity of α-lactose monohydrate, and the resulting material is similar to spray-dried lactose in behavior as a direct compression excipient. Roller compaction introduced desirable characteristics to the raw α-lactose monohydrate by inducing changes in crystallinity and particle morphology. Scanning electron microscopy results indicated that the compaction process converted some of the original torpedo-shaped crystals of α-lactose monohydrate into a more cylindrical shape with rounded edges. Compaction pressure and repetition of compaction have a significant effect on the modification of the crystallinity of the processed, raw α-lactose monohydrate.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30095020</pmid><doi>10.1080/03639045.2018.1508224</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; EBSCOhost Business Source Complete |
| subjects | Chemistry, Pharmaceutical Co-processing crystallinity Drug Compounding - methods dry granulation Excipients - chemistry lactose Lactose - chemistry Particle Size Powders Pressure roller compaction spray dried lactose Tablets xrpd |
| title | Modification of α-lactose monohydrate as a direct compression excipient using roller compaction |
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