Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, the molecular mechanisms regulating ferroptosis are largely unknown. In this study, we report that the RNA-binding protein ELAVL1/HuR plays a crucial role in regulating ferroptosis...

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Veröffentlicht in:	Autophagy 2018-12, Vol.14 (12), p.2083-2103
Hauptverfasser:	Zhang, Zili, Yao, Zhen, Wang, Ling, Ding, Hai, Shao, Jiangjuan, Chen, Anping, Zhang, Feng, Zheng, Shizhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autophagy Autophagy - drug effects Autophagy - genetics Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Death - drug effects Cell Death - physiology Cells, Cultured Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - physiology ELAVL1 Female ferritinophagy ferroptosis hepatic stellate cell Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Iron - pharmacology Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Liver Cirrhosis - chemically induced Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology liver fibrosis Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mice Mice, Inbred C57BL Middle Aged Research Paper - Basic Science Retrospective Studies Sorafenib - administration & dosage Sorafenib - adverse effects Sorafenib - pharmacology therapeutic target
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