A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone
Increasing the permeability of drugs across the cornea is key to improving drug absorption by the eye. This study presents a newly developed in situ gel loaded with nanoparticles, which could achieve controlled drug release and high ocular drug bioavailability by avoiding rapid precorneal clearance....
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| Veröffentlicht in: | Nanotechnology 2018-10, Vol.29 (42), p.425101-425101 |
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| container_end_page | 425101 |
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| container_issue | 42 |
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| container_title | Nanotechnology |
| container_volume | 29 |
| creator | Wen, Yifeng Ban, Junfeng Mo, Zhenjie Zhang, Yan An, Peigang Liu, Lizhong Xie, Qingchun Du, Youyun Xie, Baoyin Zhan, Xiaolong Tan, Liyao Chen, Yanzhong Lu, Zhufen |
| description | Increasing the permeability of drugs across the cornea is key to improving drug absorption by the eye. This study presents a newly developed in situ gel loaded with nanoparticles, which could achieve controlled drug release and high ocular drug bioavailability by avoiding rapid precorneal clearance. The physicochemical parameters of the formulation were investigated and showed uniform size, physical stability, and favorable rheological and gelling properties. Ex vivo permeation studies revealed significantly higher drug release from the in situ gel loaded with nanoparticles compared to the conventional poloxamer in situ gel and the drug solution. When compared with a marketed formulation, the in situ gel loaded with nanoparticles provided slower controlled release and higher ocular bioavailability of dexamethasone. In conclusion, the developed nanoparticle-loaded in situ gel can successfully increase drug ocular bioavailability by enhancing contact time with the ocular surface and permeation through the cornea. |
| doi_str_mv | 10.1088/1361-6528/aad7da |
| format | Article |
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In conclusion, the developed nanoparticle-loaded in situ gel can successfully increase drug ocular bioavailability by enhancing contact time with the ocular surface and permeation through the cornea.</description><subject>corneal permeability</subject><subject>gel</subject><subject>nanoparticles</subject><subject>ocular bioavailability</subject><subject>ocular drug delivery system</subject><issn>0957-4484</issn><issn>1361-6528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kM9vFSEQgInR2Nfq3ZPhaBO3HdgfsMemsWrSxIueCQuDj8rCCruN_e_Ly6s9aUICM_PNTPgIecfggoGUl6wdWDP0XF5qbYXVL8juOfWS7GDsRdN1sjshp6XcATAmOXtNTloAUfPDjvy6oktaMa5eBxp1TIvOqzcBm5C0RUt9pMWvG_2JgbqUKca9jqYWdLS0bGXVPtYoLft1r8PsDbUY_D3mB5pcff_RM9ZKSRHfkFdOh4Jvn-4z8uPm0_frL83tt89fr69uG9MKWBvRDbwfBukEE71EYTuDbtLOAZtMb4GP7YRoR-BayLG1DpxxBpFxPaDppvaMfDjOXXL6vWFZ1eyLwRB0xLQVxUHWRRIGqCgcUZNTKRmdWrKfdX5QDNRBsTr4VAef6qi4trx_mr5NM9rnhr9OK3B-BHxa1F3acqyfVQe3io-q4_X0DJharKvsx3-w_939CKlTlns</recordid><startdate>20181019</startdate><enddate>20181019</enddate><creator>Wen, Yifeng</creator><creator>Ban, Junfeng</creator><creator>Mo, Zhenjie</creator><creator>Zhang, Yan</creator><creator>An, Peigang</creator><creator>Liu, Lizhong</creator><creator>Xie, Qingchun</creator><creator>Du, Youyun</creator><creator>Xie, Baoyin</creator><creator>Zhan, Xiaolong</creator><creator>Tan, Liyao</creator><creator>Chen, Yanzhong</creator><creator>Lu, Zhufen</creator><general>IOP Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7334-9375</orcidid><orcidid>https://orcid.org/0000-0001-5564-0900</orcidid></search><sort><creationdate>20181019</creationdate><title>A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone</title><author>Wen, Yifeng ; Ban, Junfeng ; Mo, Zhenjie ; Zhang, Yan ; An, Peigang ; Liu, Lizhong ; Xie, Qingchun ; Du, Youyun ; Xie, Baoyin ; Zhan, Xiaolong ; Tan, Liyao ; Chen, Yanzhong ; Lu, Zhufen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-74625668f71758e7d4cefbaff01bc5d0293beed902a7893df0fcfcee12a6ec4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>corneal permeability</topic><topic>gel</topic><topic>nanoparticles</topic><topic>ocular bioavailability</topic><topic>ocular drug delivery system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Yifeng</creatorcontrib><creatorcontrib>Ban, Junfeng</creatorcontrib><creatorcontrib>Mo, Zhenjie</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>An, Peigang</creatorcontrib><creatorcontrib>Liu, Lizhong</creatorcontrib><creatorcontrib>Xie, Qingchun</creatorcontrib><creatorcontrib>Du, Youyun</creatorcontrib><creatorcontrib>Xie, Baoyin</creatorcontrib><creatorcontrib>Zhan, Xiaolong</creatorcontrib><creatorcontrib>Tan, Liyao</creatorcontrib><creatorcontrib>Chen, Yanzhong</creatorcontrib><creatorcontrib>Lu, Zhufen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nanotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Yifeng</au><au>Ban, Junfeng</au><au>Mo, Zhenjie</au><au>Zhang, Yan</au><au>An, Peigang</au><au>Liu, Lizhong</au><au>Xie, Qingchun</au><au>Du, Youyun</au><au>Xie, Baoyin</au><au>Zhan, Xiaolong</au><au>Tan, Liyao</au><au>Chen, Yanzhong</au><au>Lu, Zhufen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone</atitle><jtitle>Nanotechnology</jtitle><stitle>NANO</stitle><addtitle>Nanotechnology</addtitle><date>2018-10-19</date><risdate>2018</risdate><volume>29</volume><issue>42</issue><spage>425101</spage><epage>425101</epage><pages>425101-425101</pages><issn>0957-4484</issn><eissn>1361-6528</eissn><coden>NNOTER</coden><abstract>Increasing the permeability of drugs across the cornea is key to improving drug absorption by the eye. 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| source | IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | corneal permeability gel nanoparticles ocular bioavailability ocular drug delivery system |
| title | A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone |
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